Case Report Case Report of Diffuse Large B Cell Lymphoma of Uterine Cervix Treated at a Semiurban Cancer Centre in North India Vibhor Sharma, 1 Tapas Dora, 2 Mehul Patel, 3 Sankalp Sancheti, 4 and Epari Sridhar 5 1 Department of Medical Oncology, Homi Bhabha Cancer Hospital, Sangrur, Punjab 148001, India 2 Department of Radiotherapy, Homi Bhabha Cancer Hospital, Sangrur, Punjab 148001, India 3 Department of Radiodiagnosis, Homi Bhabha Cancer Hospital, Sangrur, Punjab 148001, India 4 Department of Pathology, Homi Bhabha Cancer Hospital, Sangrur, Punjab 148001, India 5 Department of Pathology, Tata Memorial Hospital, Mumbai 400012, India Correspondence should be addressed to Vibhor Sharma; vibhor81@yahoo.co.in Received 15 April 2016; Revised 12 July 2016; Accepted 13 July 2016 Academic Editor: Massimo Gentile Copyright © 2016 Vibhor Sharma et al. Tis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Lymphoma of the uterine cervix is very rare. We report a case of difuse large B cell lymphoma (DLBCL) involving the uterine cervix treated at a newly commissioned semiurban cancer centre in north India in 2015. Data for this study was obtained from the hospital electronic medical records and the patient’s case fle. We also reviewed published case reports of uterine and cervical lymphoma involving forty-one patients. We treated a case of stage IV DLBCL cervix with six cycles of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone) and intrathecal methotrexate followed by consolidation with radiotherapy. Te patient showed complete response to chemotherapy. We conclude that, in advanced stage lymphoma involving uterus and cervix, combination of chemotherapy and radiotherapy is efective in short term. 1. Introduction Non-Hodgkin’s Lymphoma (NHL) afects extranodal sites in one-third of cases. Te most commonly afected extranodal sites are the gastrointestinal tract and skin. Rarely may female reproductive organs be involved, most commonly ovary. NHL of the cervix is extremely rare. In one series, cervix was involved in 1 out of 730 cases of NHL and 1 out of 175 cases of extranodal lymphoma [1]. It is usually a high grade B cell lymphoma [2] with abnormal vaginal bleeding as the most common presenting symptom (60%) [3]. As cervical lymphomas arise from the stroma rather than the mucosa, hence cervical cytology is not very sensitive in recognizing it. We report a case of DLBCL involving uterine cervix and provide a review of literature of cervical lymphoma. 2. Case Presentation A 61-year-old postmenopausal lady presented with bleeding per vaginum and 6 kg weight loss in preceding 3 months. Her performance status was 1 (ECOG scale). Local examination revealed a 7 × 6 cm mass in the cervix and extending to lower uterus and upper third of vagina, involving both parame- tria. Rectal mucosa was uninvolved. Tere was no hep- atosplenomegaly or lymphadenopathy. Contrast Enhanced Computed Tomography (CECT) scan of chest abdomen and pelvis revealed a 8.7 × 7.9cm mass in cervix with extension into uterus and lower cervix, abutting the urinary bladder, laterally involving parametrium, encasing right ureter caus- ing mild-to-moderate hydronephrosis and posteriorly loss of fat planes with rectum; bilateral external iliac lymph nodes were enlarged (largest 2.5 × 2 cm); 1.3 cm mildly enhancing mass in uncinate process of pancreas; multiple hypodense lesions in both lobes of liver, largest being 1.5cm; and 2.8 × 2.4 cm sof tissue deposit in subcutaneous plane in right lower chest wall and multiple subcentimetric nodules in bilateral lungs (Figures 1 and 2). Bone marrow and cerebrospinal fuid were uninvolved. Cervical biopsy revealed difuse large B cell lymphoma. On immunohistochemistry, cells tested positive for CD20, MUM 1, and BCL 6; Mib 1 proliferation index was 70–80%. Viral serology for HIV, Hepatitis B surface antigen, and Hepatitis C were negative. Afer complete diagnostic Hindawi Publishing Corporation Case Reports in Hematology Volume 2016, Article ID 3042531, 4 pages http://dx.doi.org/10.1155/2016/3042531