HEPATOBILIARY ALTE A TE *Pradeep Kumar Padhi, Shivar Jimmy Narayan, Pre Sambit K Department of Gastroente ARTICLE INFO ABSTR Backg manife alterati hepato Metho Medica history functio in sele patient and BM severe of illn patient episcle Gangre and cl hepatic phosph 28(28% that ap alterati asympt Ulcera Copyright © 2018, Prashanth Vadigeri. This is an ope use, distribution, and reproduction in any medium, provi INTRODUCTION Ulcerative colitis (UC) is an idiopathic, progressive, inflammatory bowel disease. T process is limited to mucosa. Ulcerative distal rectum and extends for varying dist Clinically, it manifests most often through and/or mucus in stools, tenesmus, abdomina loss. The explicitness of intestinal symptoma the level of inflammatory process that is t disease. *Corresponding author: Pradeep Kumar Padhi, Department of Gastroenterology, S.C.B. Medic 753007, Odisha, India. DOI: https://doi.org/10.24941/ijcr.31300.07.201 ISSN: 0975-833X Article History: Received 17 th April, 2018 Received in revised form 26 th May, 2018 Accepted 09 th June, 2018 Published online 30 th July, 2018 Citation: Prashanth Vadigeri, 2018. “Hepatobiliary Current Research, 10, (7), 71137-71145. Key words: Inflammatory bowel disease (IBD), Chronic ulcerative colitis (CUC), CRP(C-Reactive protein), Primarysclerosingcholangitis(PSC), Autoimmune hepatitis (AIH), ALT(Alanine transaminase) Autoimmunesclerosingcholangitis (ASC), ALP (Alkaline transferase), Gamma Glutamyl Transferase (GGT) , pANCA (peri nuclear anti neutrophilic antibody), Ulcerative Colitis Disease Activity Index (UCDAI), EIM (Extraintestinal manifestations) , Pyoderma Gangrenosum (PG), ErythemaNodosum (EN), ASA (Aminosalysilic acid). RESEARCH ARTICLE ERATIONS IN ULCERATIVE COLITIS: A RE ERTIARY CARE CENTRE IN ODISHA ram Prasad Singh, Chitta Ranjan Panda, eetam Nath, Prasant Parida, KaibalyaRa Kumar Behera and Surya Kanta Parida erology, S.C.B. Medical College, Cuttack 753007 RACT ground and Aim: Hepatobiliary manifestations are amongs estations in chronic ulcerative colitis patients. There is ions in ulcerative colitis patients from India. The study obiliary alterations in ulcerative colitis patients admitted t ods: Consecutive patients 0f Ulcerative colitis admitted to al College, Cuttack from 0ct 2013 to April 2015 were in y of liver diseases were excluded. All patients were subje on tests and ultrasonography for evaluation of hepatobiliary ected patients. Controls were recruited from healthy subjec ts [73(65.1 %%) male; 39(34.9%) female] with ulcerative c MI were 40.2±14.01years and 21.3±3.5kg/m 2 respectively disease activity were 22(19.6%), 67(59.8%) and 23(20.5% ness was 24 months (IQR:6.5-48). Extra intestinal m ts(60.7%).40(35.7%) patients had arthralgia, 6(5.3%) eritis,2(1.7%) had stomatitis, 3(2.6%) had Erythematic N enosum. 60 (53.8%) patients developed hepatobiliary altera lay colored stool in whom MRCP revealed primary scle c steatosis, 42(37.5%) had asymptomatic transaminitis, hatase and 67(60%) had hypoalbuminmia. In control grou %) had transaminitis, 8(8%) had elevated alkaline phosphata pproximately 61% of Ulcerative colitis patients had extra inte ions are the most common (53.5%) extra intestinal mani tomatic transaminitis is the most common hepatobiliar ative colitis in the present study. en access article distributed under the Creative Commons Attribu ided the original work is properly cited. chronic-relapsing The inflammatory colitis affects the tances proximally. h diarrhoea, blood al pain and weight atology depends on the activity of the , cal College, Cuttack 18 By complementary analysis of well as laboratory parameters, UC activity as mild, moderate has therapeutic and prognostic Glickman, 1994). Chronic ul chiefly effects the gastroin associated with wide array of (EIM), the incidence of which (Rankin, 1990; Greenstein manifestations are amongst the with inflammatory bowel dise not only complicate the mana but also contribute significant Even before CUC was recogn liver changes with diffuse colo International Journal of Current Research Vol. 10, Issue, 07, pp.71137-71145, July, 2018 alterations in Ulcerative colitis: A report from a tertiary care centr Available online at http://www.journalcra.com EPORT FROM Haribhakti Seba Das, anjan Das, 7, Odisha, India st the most important extraintestinal paucity of data on hepatobiliary y was carried out to evaluate the to a tertiary care centre in Odisha. Gastroenterology Department SCB ncluded in the study. Patients with ected to clinical examination, liver y alterations. MRCP was performed cts (n=100). Results: A total of 112 colitis were included. The mean age y. Patients with mild, moderate and %) respectively. The median duration manifestations were found in 68 ) had arthritis, 13(11.6%) had Nodosum, 1(0.9%) had pyoderma ations.2(1.7%) had jaundice, pruritus erosing cholangitis. 22(19.6%) had 17(15.1%) had elevated alkaline ups 17(17%) had hepatic steatosis, ase. Conclusion: The study revealed estinal manifestations. Hepatobiliary ifestations in Ulcerative colitis and ry alterations in the patients with ution License, which permits unrestricted clinical symptoms and signs, as it is possible to clinically grade and severe. Activity assessment c significance (Humphrey, 1995; lcerative colitis (CUC) though ntestinal tract, is frequently f extra intestinal manifestation h varies between 25% and 36% et al., 1976). Hepatobiliary e most common EIM associated ease (IBD) (Danzi, 1988). They agement of the primary disease tly to mortality and morbidity. nized as a clinical entity, fatty onic ulceration were described as INTERNATIONAL JOURNAL OF CURRENT RESEARCH re in Odisha”, International Journal of