_____________________________________________________________________________________________________ *Corresponding author: E-mail: sajjad.sspe@pu.edu.pk, drsajjadaligill@gmail.com; Journal of Pharmaceutical Research International 33(39B): 250-264, 2021; Article no.JPRI.70728 ISSN: 2456-9119 (Past name: British Journal of Pharmaceutical Research, Past ISSN: 2231-2919, NLM ID: 101631759) Rehabilitation of Acute and Chronic Ankle Sprain for Male Cricketers Through Headway (Isometric, Isotonic and Proprioception) Exercises Sajjad Ali Gill 1* , Tanveer Akhtar 2 , M. Tariq Rafiq 3 , Abida Naseer 4 , Saeed Javed 5 and Hira Shahid 6 1 Department of Sports Sciences and Physical Education, University of the Punjab, Lahore, Pakistan. 2 Department of Zoology, University of the Punjab, Lahore, Pakistan. 3 Center for sports and exercise Sciences, University of Malaya, Kuala Lumpur, Malaysia. 4 Department of Physical Education and Sports Sciences, Government College University Faisalabad, Pakistan. 5 Department of Physical Education and Sports Sciences, The Islamia University of Bahawalpur, Pakistan. 6 Department of Sports Sciences and Physical Education, University of the Lahore, Pakistan. Authors’ contributions This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JPRI/2021/v33i39B32202 Editor(s): (1) Dr. Farzaneh Mohamadpour, University of Sistan and Baluchestan, Iran. Reviewers: (1) Seshagirirao Makke, Rajiv Gandhi University of Health Sciences, India. (2) Hagiu Bogdan-Alexandru, Alexandru Ioan Cuza University of Iasi, Romania. Complete Peer review History: https://www.sdiarticle4.com/review-history/70728 Received 06 May 2021 Accepted 11 July 2021 Published 03 August 2021 ABSTRACT The present study investigated that Headway (Isometric, Isotonic and Proprioception) exercises are effective for acute & chronic ankle sprain injury, which was observed through experimental research. Ninety-four amateur cricketers of age, 15-35 years (Control Injured, N=48; Headway Rehab Group N=46) with a confirmed acute or chronic ankle sprain, selected from four different cities of Punjab, Pakistan was evaluated through Star Excursion Balance Test (SEBT), Single Leg Balance test (SLB) and subject to a set of progressively increasing exercises on ground known as Headway rehab exercises which consisted of Isometric, Isotonic and proprioception protocols. Another group of the same level of cricketers (N=40) was managed parallel for comparisons. The Original Research Article