IJISET - International Journal of Innovative Science, Engineering & Technology, Vol. 1 Issue 6, August 2014. www.ijiset.com ISSN 2348 – 7968 A Greener Chemistry Approach for Synthesis of 2,3-diphenyl quinoxaline Pranita Mahadik 1 ,Devaanshi Jagwani 2 and Rupen Joshi 3 1 Medi-Caps Institute of Science and Technology, Indore, M.P., India 2 Medi-Caps Institute of Technology and Management, Indore, M.P., India 3 Choithram College of Professional Studies, Indore, M.P., India   ABSTRACT The objective of present research work is to provide green technique for synthesis of 2,3-diphenyl quinoxaline. Quinoxaline derivatives are well known in the pharmaceutical industry and have been shown to possess a broad spectrum of biological activities. Highly efficient and simple methods have been described in this manuscript for the synthesis with competent yields. Present synthesis complies with principle of Green chemistry. As part of current studies, we here in report economical practical techniques like- ultrasonic wave organic synthesisand by application of green solvents. On completion of reaction the products were characterized by IR, NMR and Mass Spectra. These methods are more convenient and reactions can be carried out in higher yield (94-97%), shorter reaction time (08mins-20mins) and milder conditions, without generation of pollution and safer to analyst. Keywords:Ultrasonic irradiation, Green chemistry, Green solvents, Organic synthesis Ecofriendly, Efficient. ___________________________________________________________________________ 1. INTRODUCTION Quinoxaline derivatives are an important class of nitrogen containing benzo heterocyclic compounds containing a ring complex made up of a benzene ring and a pyrazine ring 1 ; for medicinal chemists, since it has wide range of therapeutic uses and potential activities; acting as antimicrobial agents 2,3 , cytotoxic agents, anti-tubercular, anxiolytic, anti-HIV, antioxidant 3 , anti-inflammatory 4,5 , antimalarial, anticancer, antidepressant 2 , antibacterial, antifungal 4 . antibiotics, such as echinomycin, levomycin and actinoleutin that are known to inhibit growth of gram positive bacteria and are active against various transplantable tumors 5,6 , as well as rheumatoidarthritis, hemangioma and Kaposi's sarcoma, which are related to vasculogenesis and angiogenesis 7,8 . They are also used in the agricultural field as fungicides, herbicides and insecticides 8 , pesticides 9,10 .as well as their application in dyes, efficient electroluminescent materials, organic semiconductors, chemical controllable switches, corrosion inhibitor 9,10 ,building blocks for the synthesis of anion receptor, cavitands, dehydroannulenes, and DNA cleaving agents 8,11 .Because of their diverse pharmacological and biological properties, they have emerged as privileged structures in combinatorial drug discovery libraries 12 . Heterocycles are used in many various industries. However most of these compounds aren’t extracted from natural source, but are synthesized. Consequently, many methods have been developed for the synthesis of quinoxaline 10 , despite the progress, the synthesis of these compounds remains less than ideal. Thus, the development of environmentally friendly benign (Green Chemistry), high-yielding and clean approaches for the yield of quinoxaline derivatives still remains a highly desired goal in organic synthesis. Performing organic reactions in water has attracted much attention over the past decades due to its numerous advantages such as being considerably safe, nontoxic, environmentally friendly, and cheap. In addition, reactions in water can facilitate access to different reactivity and selectivity patterns compared with those observed in common organic solvents 13 . Development of a mild and eco-friendly one-pot synthetic protocol for these highly significant classes of compounds is desirable. Now a days recognition for the development of green synthetic protocols is increasing. 14 482