2640-2823 JOURNAL OF HEMATOLOGY AND CLINICAL RESEARCH J H C R https://www.heighpubs.org/jhcr 001 https://doi.org/10.29328/journal.jhcr.1001015 Research Article A study of coagulation profile in patients with cancer in a tertiary care hospital Gaurav Khichariya 1 , Manjula K 2 *, Subhashish Das 2 and Kalyani R 2 1 Junior Resident, Department of Pathology, SDU Medical College, Kolar, India 2 Professor, Department of Pathology, SDU Medical College, Kolar, India Introduction The complicated process of cancer triggers many physiological systems like vascular endothelial functions and hemostasis, which signiϐies the increased risk of thrombosis, which triggers thromboembolic events resulting in increased mortality and morbidity [1-3]. Tumorigenesis contributes by activation of coagulation around the perivascular region [4]. Patients with cancer of the gastrointestinal tract, pancreas, and lung are more prone to hypercoagulability [5]. Previous studies on breast cancer have also shown a hypercoagulable state with increased tissue factor, ϐibrinogen, prothrombin time (PT), Activated partial thromboplastin time (APTT) [6-8]. In patients with colorectal cancer, D-dimer levels correlate with tumor cells’ invasion at the time of surgery [9]. These ϐindings are explained by the fact that the inϐlammatory response is associated with neoplasia by changing the protein metabolism or venous stasis. Procoagulants, including tissue factor, phospholipid PS (phosphatidylserine) secreted by tumor cells, are assumed to promote angiogenesis and tumor cell growth. In Disseminated intravascular coagulation (DIC) due to the consumption of platelets and clotting factors V and VIII, ϐibrinogen decreases in quantity in blood circulation [10]. Relation of prognosis and coagulation tests for various tumors have been reported, but the concurrence of cancer and coagulation abnormality has not been reported so far. The risk in patients with malignancy has been discussed in various studies but shows conϐlicting results. Prandoni, et al. [11-13]. did not ϐind any association between patients with cancer and those without cancer. This study aims to correlate the coagulation proϐile with the frequently encountered cancers and help the clinicians detect DIC at an early stage and manage the patients at different cancer stages. Methods This is a Laboratory-based observational study done at RL Jalappa hospital and research center in the Kolar district of Karnataka. A total of 252 patients were retrospectively included. Data regarding the coagulation parameters and histopathological diagnosis, including malignancy, were collected from the Central diagnostic research laboratory (CDLS) using Laboratory information system software. Ethical clearance was taken from Institutional Ethics Committee. Patients diagnosed with malignancy proved either with trucut biopsy of the primary lesion or metastatic site or from resected specimens, between June 2018 to June 2020 on histopathology were included retrospectively, and those who received oral/parenteral anticoagulants or those with a history of thrombosis within the last three months were excluded from the study. For histopathological diagnosis, tissue sections (2-3 mm) were deparafϐinized and stained on Hematoxylin and eosin. Hemoglobin, total leukocyte counts, platelet count, were done on Sysmex XN-550, and pretreatment PT, APTT, and INR were done on Erba Manheim ECL 412 were collected for analysis. Cut off for hemoglobin of 12 mg/dl was selected to categorize the patients irrespective of their gender, into two low and normal groups. Similarly, patients with total leukocytes of more than 11000 cells/cumm were categorized into the elevated group instead of normal. Data were entered into Microsoft Excel datasheet and analyzed using SPSS 22 version software. Categorical data are represented in the form of frequencies and proportions. More Information *Address for Correspondence: Dr. Manjula K, Professor, Department of Pathology, SDU Medical College, Kolar, India, Tel: +918951374212; Email: gkpmanju966@gmail.com Submitted: January 24, 2021 Approved: February 09, 2021 Published: February 10, 2021 How to cite this article: Khichariya G, Manjula K, Das S, Kalyani R. A study of coagulation profile in patients with cancer in a tertiary care hospital. J Hematol Clin Res. 2021; 5: 001-003. DOI: 10.29328/journal.jhcr.1001015 Copyright: © 2021 Khichariya G, et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited OPEN ACCESS