International Journal of Science and Research (IJSR) ISSN (Online): 2319-7064 Index Copernicus Value (2015): 78.96 | Impact Factor (2015): 6.391 Volume 6 Issue 3, March 2017 www.ijsr.net Licensed Under Creative Commons Attribution CC BY Evaluation of Antidiabetic Potential of A Novel Formulation from Prophetic Medicine in Streptozotocin-Induced Diabetic Balb/C Mice Eman Elm .E. Elaswed 1 , Moklesur Rahman Sarker 2 1 Faculty of Sciences, Lincoln University College Malaysia Mayang Jaya, 47301, Petaling Jaya, Selangor Darul Ehsan, Malaysia 2 Faculty of Pharmacy, Lincoln University College Malaysia Mayang Jaya, 47301, Petaling Jaya, Selangor Darul Ehsan, Malaysia Abstract: Diabetes is a common, chronic and expensive disease that is threatening the health of generations of people all around the world. Diabetes mellitus is a disorder that affects the body’s ability to make or use insulin and it remains an incurable disorder in spite of intense research. Prophetic Medicine is the total authentic Hadith narrated by the Prophet (peace be upon him), which carries incredible values for the administration of diabetes. The present study aimed to develop a new formulation from Prophetic Medicine and to evaluate its therapeutic potential for the effective use in diabetes for avoiding major adverse effects in animal model. Towards this aim, diabetes was induced to Balb/c mice with the injection of streptozotocin (160 mg/kg). The mice were treated with the formulation of Prophetic medicine (PMFD) at the doses of 200, 400, 600 mg/kg and metformin at dose of 200 mg/kg orally. The glucose levels were measured on first day for 3 hours, second and third day for 2 hours and 2 weeks before and after treatment with the PMFD. Non-diabetic mice were used as a negative control and diabetic mice without treatment was used as a positive control .The formulation (PMFD) at the dose of 200, 400 and 600 mg/kg shows significant reduction in post-prandial plasma glucose level and body weight, whereas metformin of 200 kg/mg shows significant reduction of glucose level on second and third day.Thus, the present formulation of Prophetic medicine can be recommended for the prevention and treatment of diabetes. This data can support for biomedical research efforts that can lead to prevention, treatment and possibly even cures for diabetes. Keywords: Diabetes Multiuse, Prophetic medicine, Plasma Glucose level, Balb/c mice, Body Weight Streptozotocin , Metformin 1. Introduction Diabetes mellitus (DM) is a clinical syndrome associated with deficiency of insulin secretion or action. It is considered one of the largest emerging threats to health in the 21st century. Insulin secretion is subject to control by nutrients, hormonal, neural, and pharmacological factors. Among these glucose is the most important regulator of insulin secretion machinery (Mosley et al., 2013). It is estimated that there will be 380 million persons with DM in 2025 (Atkins & Zimmet, 2010). Despite considerable progress in the treatment of diabetes by hypoglycemic agents, search for newer drugs continues because the existing synthetic drugs of diabetes are associate with the increased risk of many complications, such as cardiovascular disease, cancer, renal impairment (Cassidy et al., 1999). Many prophetic medicine plants have been used for the treatment of diabetes mellitus. Out of these only a few have been evaluated as per modern system of medicine. From many such plants, only extracts have been prepared and their usefulness evaluated in experimental diabetes in animals. Unfortunately, there is a lack of scientific investigations to discover and establish the effectiveness of Prophetic medicines for the treatment of different diseases. Towards, achieving this goal present study was performed. In the current study, streptozotocin (STZ)-induced diabetic mice were treated by Prophetic medicine formula for Diabetic (PMFD) and subjected to management of blood glucose level and body weight. The aim of the present study is to investigate or evaluate the therapeutic potential of PMFD for management and treated streptozotocin (STZ)-induced diabetic mice with avoiding major adverse effects. This study hypothesize that diabetic mice treated with PMFD will significantly reduce fasting plasma glucose FPG and post-prandial blood glucose PPBG levels. The result from this study might be significantly contribute for the management of plasma blood glucose of STZ- induced diabetic Balb/c mice or minimizing the side-effects of diabetic medication. Thus, it can be a clue of new drug for the effective management of diabetes improving the quality of life for diabetic patients. 2. Objectives The aim of the current research is to develop a new formulation from Prophetic medicines and to evaluate its therapeutic potential for the effective management of plasma glucose STZ- induced diabetic Balb/c mice with avoiding major adverse- effects in animal model. 3. Methodology 3.1 Materials 3.1.1. Prophetic materials used in PMFD The Essential Prophetic Medicine (PM) materials were selected based on literature survey and their use in traditional medicines. These materials were purchased from Arabian shops and Malaysian markets as well. The list of the prophetic materials used in the study are listed in Table 1. Paper ID: ART20171623 DOI: 10.21275/ART20171623 857