Open Journal of Ophthalmology, 2018, 8, 133-139 http://www.scirp.org/journal/ojoph ISSN Online: 2165-7416 ISSN Print: 2165-7408 DOI: 10.4236/ojoph.2018.83017 Jul. 25, 2018 133 Open Journal of Ophthalmology Quantitative Assessment of Foveal Avascular Zone in Patients with Early and Intermediate Nonexudative Age-Related Macular Degeneration Using Optical Coherence Tomography-Angiography Vladimir Stavrev, Nelly Sivkova, Desislava Koleva-Georgieva Department of Ophthalmology, Faculty of Medicine, Medical University of Plovdiv, Plovdiv, Bulgaria Abstract Optical coherence tomography-angiography (OCT-A) is a relatively new non-invasive imaging technique which provides three-dimensional visualiza- tion of the retinal and choroidal microvasculature. Recently, OCT-A is widely used in the diagnosis of age-related macular degeneration (AMD). Purpose: To compare 3 quantitative indexes of foveal avascular zone (FAZ)—area (A), perimeter (Pm), and circularity (C) in patients with early and intermediate nonexudative AMD and healthy subjects using OCT-A. Methods: Eighty-nine patients with nonexudative AMD (n = 89 eyes) were enrolled in the study. They were compared with sex- and age-matched control group of 66 healthy subjects (n = 66 eyes). The patients with nonexudative AMD were divided in- to 2 subgroups—early AMD (n = 42 eyes) and intermediate AMD (n = 47 eyes). All participants underwent OCT-A (3 × 3 mm scans, Cirrus HD-OCT, Angioplex, Carl Zeiss Meditec, Dublin, CA). Results: There was no statistically significant difference in all 3 assessed indexes between the early AMD sub- group and the control group (A − P = 0.139; Pm − P = 0.230; and C − P = 0.191). There was also no statistically significant difference in all 3 assessed indexes between the intermediate AMD subgroup and the control group (A − P = 0.106, Pm − P = 0.124, and C − P = 0.102, respectively). Conclusions: According to our results from the assessment of FAZ in patients with early and intermediate AMD, we hypothesize that macular perfusion remains fairly unchanged in the nonexudative stages of the disease. OCT-A is a reliable tech- nique for visualizing and quantifying FAZ in patients with nonexudative AMD. How to cite this paper: Stavrev, V., Siv- kova, N. and Koleva-Georgieva, D. (2018) Quantitative Assessment of Foveal Avascu- lar Zone in Patients with Early and Inter- mediate Nonexudative Age-Related Macu- lar Degeneration Using Optical Coherence Tomography-Angiography. Open Journal of Ophthalmology, 8, 133-139. https://doi.org/10.4236/ojoph.2018.83017 Received: May 29, 2018 Accepted: July 22, 2018 Published: July 25, 2018 Copyright © 2018 by authors and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/ Open Access