https://doi.org/10.1177/2333794X211015524 Global Pediatric Health Volume 8: 1–8 © The Author(s) 2021 Article reuse guidelines: sagepub.com/journals-permissions DOI: 10.1177/2333794X211015524 journals.sagepub.com/home/gph Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). Original Research Article Introduction Worldwide it is estimated that there are 133 million live births annually, 5.9 million under-five deaths with 3.7 deaths during the neonatal period, and 3 million still- born. A total of 98% of these deaths occur in the devel- oping world. The average neonatal mortality rate in developing countries is 31/1000 live births while it is 4/1000 live births in developed countries. In Africa, the sub-Saharan regions of eastern, western, and central Africa have neonatal mortality between 40 and 46/1000 live births. Stillbirth rates have also remained high in sub-Saharan Africa with the rate of 38/1000 live births. 1 In Ethiopia, 1 in every 35 children dies within the first month, 1 in every 21 children dies before celebrating 1015524GPH XX X 10.1177/2333794X211015524Global Pediatric HealthSeyoum et al. research-article 2021 1 Tefera Hailu Memorial Hospital, Waghimra Zone, Sekota, Ethiopia 2 Ethiopian Public Health Association, Addis Ababa, Ethiopia 3 Department of Epidemiology and Biostatistics, Institute of Public Health, University of Gondar, Gondar, Ethiopia 4 School of Nursing and Midwifery, Haramaya University, Harar, Ethiopia *Corresponding Author: Simon Birhanu, School of Nursing and Midwifery, Haramaya University, Harar, Ethiopia. Email: abiubirhanu1221@gmail.com Magnitude and Determinants of Adverse Perinatal Outcomes in Tefera Hailu Memorial Hospital, Sekota Town, Northern Ethiopia Eshetu Seyoum 1 , Alemayehu Bekele 2 , Adino Tesfahun Tsegaye 3 , and Simon Birhanu* 4 Abstract Background. Of 133 million births globally, 3.7 million died in the neonatal period and 3 million are stillborn. The perinatal mortality rate in Ethiopia is 46 per 1000 pregnancies. However, area-specific information is limited in this regard. Therefore, this study aimed to determine the magnitude and determinants of adverse perinatal outcomes in Northern Ethiopia. Method. An institution-based cross-sectional study was conducted by reviewing the medical records of mothers who gave birth between September 2015 and August 2016. The completeness and consistency of data were checked. Descriptive statistics were computed. A multinomial logistic regression model was fitted to identify determinants of adverse perinatal outcomes. Odds ratio with 95%CI was used and variables that had a P-value of < 0.05 in the final model were considered statistically significant. Result. The magnitude of adverse perinatal outcomes was 214/799(27.47 %). Out of that, 10.8% had a perinatal mortality outcome, and 16.7% had a perinatal morbidity. Not using modern contraceptives(AOR = 1.7, 95% CI: 1.1-2.7), labor induction or augmentation(AOR = 3.0, 95% CI: 1.2-7.8), obstetric complications(AOR = 2.2, 95% CI: 1.1-4.5), attending antenatal care(AOR = 0.4, 95% CI: 0.2-0.8), primigravida (AOR = 0.5, 95% CI: 0.3-0.9), had no history of medical illness(AOR = 0.5, 95% CI: 0.3-0.8), and urban residency(AOR = 1.9, 95% CI, 1.1-2.9) were the significant determinants of perinatal outcome. Conclusion. The magnitude of adverse perinatal outcomes was considerable and 1 in 5 neonates either had morbidity conditions or died. Improving family planning utilization, ANC, referral linkage, and management of obstetric complications could help to reduce the undesirable consequences of perinatal outcomes. Keywords low birth weight, prematurity, perinatal mortality, stillbirth, Ethiopia Received March 26, 2021. Accepted for publication April 17, 2021.