In vitro Anti-microbial Activity and Wound Healing Evaluation of Acacia Gum Arabia Aqueous Cream Suliman RS 1* , Ali H 2 , Alamer A 1 , Aleid N 1 , Abu-Jafal A 3 , Abdulgadir R 4 , Omer M 1 1 College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences Ministry of National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia; 2 Department of Pharmaceutics, University of Khartoum, Sudan; 3 College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences Ministry of National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia; 4 Faculty of Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia ABSTRACT Objective: The aim of the present study was to characterize the antimicrobial properties of Acacia Gum Arabia crude extracts and Acacia Gum Arabia aqueous cream against certain selected quality control microorganisms. Methodology: A serial concentrations were prepared 2.5%, 5%, 10%, 15%, and 20% of Acacia Gum Arabia. An aqueous cream with 5% concentration of Acacia Gum Arabia were prepared and evaluated. A quality control tests were conducted to check the stability, organoleptic properties and pH of the cream. An in vitro evaluation against Gram positive bacteria (Bacillus subtilis and Staphylococcus aureus), Gram negative bacteria (Escherichia coli, and Pseudomonas aeroginosa) and yeast (Candida albicans). The Minimum Inhibitory Concentration (MIC) were determined. Results: Out of sex (6) tested microorganisms, it is found that 5% is the optimum concentration that most of the microorganisms are reported to shows zone of inhibitions. A further experiments were conducted for minimum inhibitory concentrations (MIC). The MIC values are found to be Proteus 1.25%, Shigella 2.5-1.5%, Staphylococcus epidermidis 1.25%, and Klebsiella 2.5%. The quality control tests for Acacia Gum Arabia cream reveals that for the spreadability test the measured diameter of each types (spreadability), in which the average diameter of aqueous cream and acacia cream ware 2.4 and 2.2 ± 0.14, respectively. The topical treatment with Acassia gum cream showed significant healing effect on excision wounds and demonstrated an important role in the inflammation process by increasing antioxidant enzyme activities, thereby accelerating the wound healing process and reducing tissue injury. Conclusion: it can be concluded that Acacia Gum Arabia demonstrate an antibacterial activity for certain types of bacterias. And the Acacia Gum Arabia cream can be used as an antibacterial cream. Keywords: Acacia Gum Arabia aqeous cream; Cream quality control; Disc diffusion method; and Minimum Inhibitory Concentrations (MIC) INTRODUCTION Acacia Gums, also known as Gum Arabic (GA), is one of the most commonly used product for a wide range of applications in different pharmaceutical dosage forms. GA is a sap (a fluid) found in the vacuoles (small cavities) from the branches of Acacia trees) [1]. There are a variety of GA species around the world. The gum is usually collected manually after exposing the tree to stressful conditions like injury and draught (Figure 1). Natural Products Chemistry & Research Research Article Correspondence to: Suliman RS, College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences Ministry of National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia, Tel: 0534777481; E-mail: sulimanr@ksau-hs.edu.sa Received: February 03, 2020; Accepted: February 17, 2020; Published: February 24, 2020 Citation: Suliman RS, Ali H, Alamer A, Aleid N, Abu-Jafal A, Abdulgadir R, et al. (2020) In vitro Anti-microbial Activity and Wound Healing Evaluation of Acacia Gum Arabia Aqueous Cream. Nat Prod Chem Res. 8:369. DOI: 10.35248/2329-6836.20.8.369 Copyright: © 2020 Suliman RS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Nat Prod Chem Res, Vol.8 Iss.1 No:369 1