Introduction: The liver is the most common site for colorectal cancer (CRC) metastases. Hepatocellular carcinoma (HCC) is the most common type of hepatobiliary cancer. Unresectable HCC and unresectable hepatic CRC me- tastases are beyond the scope of curative treatments thus directing disease management to a more palliative approach aimed at increasing survival and improving the quality of life. Radioembolization with Yttrium-90 (Y90) represents an alternative treatment option in those patients. The objective of this study was to evaluate outcomes after treatment with Y90. Method: A retrospective review of patients undergoing Y90 glass microsphere treatment for metastatic CRC and HCC from 06-2008 to 06-2015 was conducted. Multivariable analysis of factors related to overall sur- vival (OS) was performed using the Cox proportional hazard and OS estimates were calculated using the Kaplan- Meier method. Results: We identified 39 patients (CRC N: 24, HCC N: 15). Median and 2-year OS for CRC were respectively 12.0 months and 22.5%. Median and 2-year OS for HCC were respectively 10.8 months and 10%. Patients in both groups who did not respond after 3 months of radioembolization had a significant worse OS. More than 2 lines of treatment (surgery and/or chemotherapy) before radioembolization were predictors of worse OS. Toxicities were in general mild and only 2 patients experienced grade 3/4 biochemical toxicity. Conclusion: Yttrium-90 represents a good palliative treatment option and is associated with acceptable OS and minimal morbidity in our series. EP01A-056 IMPACT OF TOTALLY LAPAROSCOPIC COMBINED MANAGEMENT OF COLORECTAL CANCER WITH SYNCHRONOUS HEPATIC METASTASES ON SEVERITY OF COMPLICATIONS. A PROPENSITY-SCORE BASED ANALYSIS F. Ratti 1 , M. Catena 1 , S. Di Palo 2 , C. Staudacher 2 and L. Aldrighetti 1 1 Hepatobiliary Surgery Division, and 2 Gastrointestinal Surgery Division, IRCCS San Raffaele Hospital, Italy Background: Thanks to widespread diffusion of mini- mally-invasive approach in the setting of both colorectal and hepatic surgery, the interest in combined resections for colorectal cancer and synchronous liver metastases (SCLM) by totally laparoscopic approach (TLA) has increased. Aim of this study was to compared outcome of combined resections for SCLM performed by TLA or by open approach, in a case-matched design. Methods: All 25 patients undergoing combined TLA for SCLM at San Raffaele Hospital in Milano were compared in a case-match analysis with 25 out of 91 patients under- going totally open approach (TOA group). Groups were matched with 1:2 ratio using propensity scores based on covariates representing disease severity. Main endpoints were postoperative morbidity and long term-outcome. The Modified Accordion Severity Grading System was used to quantify complications. Results: The groups resulted comparable in terms of pa- tients and disease characteristics. The TLA Group, as compared to the TOA Group, had lower blood loss (350 mL versus 600 mL), shorter postoperative stay (9 versus 12 days), lower postoperative morbidity index (0.14 versus 0.20) and severity score for complicated patients (0.60 versus 0.85). Colonic anastomosis leakage had the highest fractional complication burden in both groups. In spite of comparable long-term overall survival, the TLA group had better recurrence-free survival. Conclusion: TLA for combined resections is feasible and its indications can be widened to encompass a larger pop- ulation of patients, provided its benefits in terms of reduced overall risk and severity of complications, rapid functional recovery and favourable long-term outcomes. EP01A-057 IS 1MM AN ACCEPTABLE RESECTION MARGIN IN PATIENTS HAVING LIVER RESECTION FOR COLORECTAL LIVER METASTASES? Y. M. Goh 1 , E. L. Goh 2 , Y. L. Goh 1 , C. Harris 1 , D. Chang 1 , A. Kausar 1 , R. Prescott 3 and D. Subar 1 1 Department of Hepato-Biliary Surgery, Royal Blackburn Hospital, East Lancashire Hospitals NHS Trusts, 2 Imperial College London, and 3 Department of Pathology, Royal Blackburn Hospital, East Lancashire Hospitals NHS Trusts, United Kingdom Introduction: Conflicting reports continue to be published on the impact of resection margin (RM) on recurrence in patients undergoing liver resection (LR) for colorectal liver metastases (CRLM). RM of 1cm was the accepted gold standard but recent evidence suggests no difference in survival with RM of up to 1mm with modern chemo- therapy. However, a RM5mm is associated with increased incidence of local recurrence. This study assesses the impact of RM1cm on the incidence of overall and liver recurrence in patients un- dergoing resection for CRLM. Methods: This is a retrospective study of all patients who underwent resection for CRLM from August 2005 to December 2011with a RM1cm. Outcome was any or liver recurrence. Parameters assessed included age, gender, presence of synchronous disease at the time of colorectal resection, chemotherapy use (pre-and post-operative), RM, size of largest metastasis and number of lesions resected. All categorical and continuous variables were analysed using Chi-Square and/or Fisher’s Exact Test and Mann- Whitney U test respectively. All factors with p-value0.1 was entered into multivariate analysis. Results: 71 (54.1%) of 131 patients who underwent LR between the study period had R1resections. Mean age was 67.5  9.8 years with male:female ratio 50:21. A median of 1 (range1e4) lesion were resected measuring a mean of 38.8 (range4e145mm). Univariate analysis showed increased incidence of recurrence in R1 resections (any HPB 2016, 18 (S1), e1ee384 e182 Electronic Poster Abstracts