Short title: DR3 regulates peritoneal inflammation © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ 1 1 Death Receptor 3 promotes chemokine directed leukocyte recruitment in acute 2 resolving inflammation and is essential for pathological development of 3 mesothelial fibrosis in chronic disease 4 5 William Victor Perks* ‡ , Ravinder Kaur Singh* ‡ , Gareth Wyn Jones † , Jason Peter Twohig* † , Anwen 6 Sian Williams † , Ian Robert Humphreys*, Philip Russel Taylor † , Simon Arnett Jones † , Eddie Chung 7 Yern Wang* § 8 9 Departments of *Medical Microbiology & Infectious Disease and † Rheumatology, Cardiff Institute of Infection & 10 Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK 11 12 ‡ These authors contributed equally to the manuscript 13 14 No of pages: 25 (including References and Figure legends); 4 Figures 15 16 Sources of support: WVP was supported by a PhD studentship from the I3-IRG, joint funded by the British Medical 17 Research Council (MRC) and the School of Medicine, Cardiff University awarded to ECYW and SAJ. JPT was employed 18 on MRC grant G0901119 awarded to ECYW and IRH. RKS was funded by BBSRC/GSK CASE studentship 19 BB/H530589/1. 20 21 § Corresponding author: Dr. E.C.Y. Wang, Department of Medical Microbiology & Infectious Disease, Cardiff Institute 22 of Infection & Immunity, School of Medicine, Cardiff University, Henry Wellcome Building, Heath Park, Cardiff CF14 23 4XN, UK 24 e-mail: wangec@cf.ac.uk 25 26