|| ISSN(online): 2589-8698 || ISSN(print): 2589-868X || International Journal of Medical and Biomedical Studies Available Online at www.ijmbs.info NLM (National Library of Medicine ID: 101738825) Index Copernicus Value 2019: 79.34 Original Research Article Volume 5, Issue 6; June: 2021; Page No. 72-76 72 | Page ROLE OF HEMATOLOGICAL PARAMETERS IN EARLY DIAGNOSIS OF COVID-19 IN A TERTIARY CARE CENTRE Dr. Angira Saha 1 , Dr. Sakar Saxena 2 , Dr. Romi Srivastava 3 & Dr. Sanjeev Narang 4 PG Resident 2 nd Year 1 , PG Resident 2 nd Year 2 , Associate Professor 3 , Professor and HOD 4 1,2,3&4 Dept. of Pathology, Index Medical College Hospital and Research Centre, Indore Article Info: Received 26 April 2021; Accepted 13 June 2021 DOI: https://doi.org/10.32553/ijmbs.v5i6.1960 Corresponding author: Dr. Sanjeev Narang Conflict of interest: No conflict of interest. Abstract Aim: To evaluate the role of biomarkers from blood samples of COVID-19 patients admitted in Index Medical College Hospital & R.C. Material & Methods: Hematological parameters such as Neutrophil lymphocyte ratio (NLR), Platelet lymphocyte ratio (PLR) & Systemic Inflammatory Index (SII) were studied in RT-PCR positive patients to evaluate the utility of these parameters for early diagnosis of COVID-19. Results: The study showed that there was statistically significant difference in test groups in reference to Neutrophil lymphocyte ratio (NLR) & SII values (p<0.05). But no statistically significant difference was observed between test groups in reference to Platelet lymphocyte ratio (PLR) values (p>0.05). Conclusion: Leukocyte, Neutrophil, NLR & SII values can be used in the early diagnosis of COVID-19. Keywords: NLR, SII, Leukocyte, Neutrophil Introduction: At the end of 2019 novel coronavirus i.e. SARS-CoV-2 emerged in Wuhan, China [1] . 115 million cases have been diagnosed worldwide till 3 rd March,2021 with 2.56 million deaths. SARS-CoV-2 was recognized as a public health concern & was declared as pandemic on 11 th March,2020 by WHO [2] . Various modes of transmission of this virus are observed out of which airborne transmission via aerosols is suspected to be the main mode. Other modes are fomites & GI tract [7] . Due to the short time of onset of Acute Respiratory Distress Syndrome after admission to hospital & high mortality rates in COVID-19; an early diagnosis by evaluating hematological parameters play an important role as they provide information to the physicians regarding the ongoing inflammatory processes [3] . Complete blood counts (CBC) are inexpensive, readily available and easy to perform. Hematological parameters from CBC which provide information regarding the inflammatory process are the counts of leukocyte, neutrophil, lymphocyte & platelet and we further calculate certain ratios from these values. Therefore, these ratios can be used as inflammatory markers as indicators of early inflammation [4-6] . In early onset of COVID-19 infection neutrophils are the first responders showing neutrophilia & relative lymphopenia and ratio of these two parameters i.e NLR is also used as an inflammatory marker [8] . Use of circulating biomarkers themselves as well as their ratios to one another representing inflammation & the immune response have been considered as an early diagnostic indicator in COVID- 19 positive patients as per previous research work [9] . NLR ratio= Absolute neutrophil count/ Absolute lymphocyte count PLR ratio= Absolute platelet count/ Absolute lymphocyte count [10] . * Use of the optimum cut-off values of laboratory results to discern severe from mild/moderate COVID-19 infection:- The analyses of optimal cut off values were calculated by the ROC analysis as no unified laboratory reference value was found. The optimal cut off values were 3.3, 180 & 479.1 for NLR, PLR & SII respectively [10,14] . Aim To evaluate the role of biomarkers from blood samples of COVID-19 patients admitted in Index Medical College Hospital & R.C. Objective 1. To investigate the blood sample of the patients admitted in Index Medical College Hospital & Research Centre with positive RT-PCR results.