77 www.jtm.viamedica.pl ORIGINAL ARTICLE Journal of Transfusion Medicine 2017, tom 10, nr 3, 77–83 Copyright © 2017 Via Medica ISSN 1689–6017 Address for correspondence: Dr. Shamee Shastry, MD Professor & Head, Department of Immunohematology & Blood Transfusion, Kasturba Medical College, Manipal University, Manipal- 576104, Karnataka, Mobile: +91-9743489837, Phone: +91-820-2922448, e-mail: shamee.girish@manipal.edu Clinical Use of Fresh Frozen Plasma in a Tertiary Care Hospital from India Zastosowanie kliniczne świeżo mrożonego osocza w szpitalu referencyjnym w Indiach Manish Raturi, Shamee Shastry, Mohandoss Murugesan, Poornima B Baliga Department of Immunohematology & Blood Transfusion, Kasturba Medical College, Manipal University, Manipal-576104, Karnataka Abstract Background. Increased utilization of fresh frozen plasma (FFP) over the last decade has caused a rising trend in its unjustifed usage exposing recipients to both infectious and non- -infectious hazards. The aim of the study was to observe the pattern of clinical use of plasma at a tertiary care hospital from India. Material and methods. Prospective analysis of all the requests raised for plasma was carried out. Indicators namely homogeneity of the requisition forms, patient demographics, indications for transfusion, dosage, pre-transfusion coagulation parameters and adverse events were noted. Appropriateness was defned based on compliance to both national and international standards. Data was analyzed using SPSS version 20 (IBM, USA). Results. Total nine hundred ninety eight patients (Males: 66%) received 4991 units of plasma at an average of two episodes per patient. Majority were adults 83.6% (n = 835). Primary users were internal medicine (32%) and plastic surgery (17%) respectively. Most common indication was bleeding with coagulopathy seen in 41% (411/998) patients. Ave- rage plasma volume administered was 456.2 ± 287.4 (17 to 2800) mL per episode. Pre- -transfusions INR value was available in only 63.2% (n = 1317) episodes. Overall, 56% (n = 1169) episodes were deemed appropriate. Total 0.28% plasma related adverse reactions were seen and reported to the national hemovigilance database. Mortality in the study group was 7.2%. Conclusion. Existing transfusion practices for plasma use were moderately compliant with the standards. Commonest indications for inappropriate FFP use were for low protein states and prophylaxis without any evidence of bleeding. Key words: fresh frozen plasma, appropriateness, clinical usage, guidelines J. Transf. Med. 2017; 10: 77–83 Streszczenie Wstęp. W ciągu ostatniej dekady znacznie zwiększyło się zużycie świeżo mrożonego osocza (fresh frozen plasma, FFP), co spowodowało rosnącą tendencję do nieuzasadnionego stosowa- nia FFP, a tym samym narażenie pacjentów na ryzyko związane z zakażeniami i niezakaźnymi