Newcastle University ePrints von Stosch M, Davy S, Francois K, Galvanauskas V, Hamelink JM, Luebbert A, Mayer M, Oliveira R, O'Kennedy R, Rice P, Glassey J. Hybrid modeling for quality by design and PAT - benefits and challenges of applications in biopharmaceutical industry. Biotechnology Journal 2014, 9(6), 719-726. Copyright: This is the accepted version of the following article. von Stosch M, Davy S, Francois K, Galvanauskas V, Hamelink JM, Luebbert A, Mayer M, Oliveira R, O'Kennedy R, Rice P, Glassey J. Hybrid modeling for quality by design and PAT - benefits and challenges of applications in biopharmaceutical industry. Biotechnology Journal 2014, 9(6), 719-726, which has been published in final form at http://dx.doi.org/10.1002/biot.201300385 Further information on publisher website: http://onlinelibrary.wiley.com/ Date deposited: 09-02-2015 Version of file: Accepted Version This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License ePrints – Newcastle University ePrints http://eprint.ncl.ac.uk