Keywords: Mitochondrial Biogene- sis; Cell Senescence; Retrograde Signaling; Medicinal Herbs *Correspondence to Author: Marcelo Ferro Sciences Department at Nutrition Formulators Inc., 10407 N Comme- rce Parkway, Miramar, Fl 33025 Mi- ramar, Fl, USA. How to cite this article: Ferro M., Graubard A., Escalante P., Ledezma R., Channan G., Mia N., Dotres V., Bencomo Y., Datri P.. Mitochondrial Metabolism, Dys- functions in Senescence Cell and the Possible Interventions through Herbal Medicines. International Journal of Aging Research, 2021; 4:78. eSciPub LLC, Houston, TX USA. Website: https://escipub.com/ Ferro M. et al., IJOAR, 2021; 4:78 International Journal of Aging Research (ISSN:2637-3742) Review Article IJOAR (2021) 4:78 Mitochondrial Metabolism, Dysfunctions in Senescence Cell and the Possible Interventions through Herbal Medicines The mitochondria are the cell`s powerhouse. They are consid- ered ubiquitous organelles of all eukaryotic cells, being respon- sible for the cell’s life and death cycle. Through stimuli in the environment in which they live, mitochondria can modulate their own biogenesis as well as signal retrograde to the nucleus to modify the structure of their proteins. Since the mitochondrial genome contains only 37 genes, much of the encoding of its pro- teins depends on the nuclear genome. Thus, the communication between mitochondria and the nucleus seems to be a target of science in understanding the pathologies associated with this organelle. Some medicinal herbs have been shown to infuence mitochondrial biogenesis, such as Gynostemma pentaphyl- lun (GP) and berberine, which increase the phosphorylation of proteins AMPactivated protein kinase (AMPK). Just as GP and berberine phosphorylate AMPK in signaling for mitochondrial biogenesis, the sesquiterpene beta-caryophyllene (BCP) demon- strated positive results in reorganizing mitochondrial transcription factors, being an agonist of the peroxisome proliferatoractivated alpha receptor (PPAR-α). Another plant derivative, the non-psy- choactive cannabinoid known as cannabidiol (CBD), has been showing control in the metabolism of calcium in the mitochondri- al matrix. In this review, we seek to get a closer look at the bio- chemical mechanisms of action of some of these plants, as well as their synergies in the results of different treatments. In the view of oriental medicines, the use of associated medicinal herbs has always been part of their treatment protocols. However, the efectiveness of these treatments in relation to plant synergy can be observed in future clinical trials for better understanding. Ferro M. * , Graubard A., Escalante P., Ledezma R., Channan G., Mia N., Dotres V., Bencomo Y. and Datri P. FG Scientifca and Science Department at Nutrition Formulators Inc., Miramar, Fl, USA. ABSTRACT IJOAR: https://escipub.com/international-journal-of-aging-research/ 1