~ 145 ~ The Pharma Innovation Journal 2021; SP-10(3): 145-149 ISSN (E): 2277- 7695 ISSN (P): 2349-8242 NAAS Rating: 5.23 TPI 2021; SP-10(3): 145-149 © 2021 TPI www.thepharmajournal.com Received: 06-01-2021 Accepted: 09-02-2021 Dharmendra Singh Faculty of Veterinary and Animal Sciences, WBUAFS Belgachia Kolkata, West Bengal, India Ajay Prakash Department of Anatomy, College of Veterinary Science & Animal Husbandry U.P. Pandit Deen Dayal Upadhyaaya Pashu Chikitsa Vigyan Vishwavidyalay Mathura, Uttar Pradesh, India MM Farooqui Department of Anatomy, College of Veterinary Science & Animal Husbandry U.P. Pandit Deen Dayal Upadhyaaya Pashu Chikitsa Vigyan Vishwavidyalay Mathura, Uttar Pradesh, India Sri Prakash Singh Department of Anatomy, College of Veterinary Science & Animal Husbandry U.P. Pandit Deen Dayal Upadhyaaya Pashu Chikitsa Vigyan Vishwavidyalay Mathura, Uttar Pradesh, India Avnish Kumar Gautam Faculty of Veterinary and Animal Sciences, WBUAFS Belgachia Kolkata, West Bengal, India Ajeet Kumar Jha Faculty of Veterinary and Animal Sciences, WBUAFS Belgachia Kolkata, West Bengal, India Keshav Kumar Faculty of Veterinary and Animal Sciences, WBUAFS Belgachia Kolkata, West Bengal, India Corresponding Author: Avnish Kumar Gautam Faculty of Veterinary and Animal Sciences, WBUAFS Belgachia Kolkata, West Bengal, India Histomorphogenesis of exocrine part of pancreas in prenatal goat (Capra hircus) Dharmendra Singh, Ajay Prakash, MM Farooqui, Sri Prakash Singh, Avnish Kumar Gautam, Ajeet Kumar Jha and Keshav Kumar Abstract The stained foetal serial sections of early prenatal stage showed that the primordium of foetal goat pancreas was present in close vicinity of developing duodenum. At 69 day old goat foetus the pancreatic parenchyma was formed by tubules of different length and diameter, tubular buds, blood capillaries and islets of Langerhans. The beginning of the process of acini formation in the foetal goat pancreas was first observed from 76 days of gestation. Cells of several buds became loosely arranged and their peripheral cells began to arrange in the form of either a complete or a part of circle to form a central lumen. From 115 days onwards the cytoplasm of few acinar cells around the nucleus had a little bluish tinge and centroacinar cells were seen in few acini. From 132 days to full term foetus the pancreas was chiefly formed by developed acini, however at few places some immature acini were also found. Keywords: Pancreas, histogenesis, exocrine part, prenatal goat Introduction The pancreas is an organ containing two distinct population of cells, the exocrine cells that secrete enzyme into the digestive tract and endocrine cells that secrets hormones into the bloodstream (J.M.W. Slack, 1995) [10] . The exocrine parts made up of acini or alveoli. Each acinus has a single layer of acinar cells with a lumen in the centre. The acinar cells contain zymogen granules, which possess digestive enzyme i.e. pancreatic juice. These enzymes have greatest role in digestion of proteins, lipids and carbohydrate. So alteration and impairment in the structure of foetal exocrine parts cause profound effects on performance of goat. Publication devoted to the histogenesis of these part of foetal goat pancreas is scanty. Therefore, present study was undertaken to see the origin and development of these parts of pancreas during different stage of gestation. Material and Methods The present study was conducted on the pancreas of 24 goat foeti of either sex ranging from 42 days to 147 days of gestation. In current research, ethical approval is exempted from the university. The samples were taken from the aborted foeti which has collected from the clinics of college of Veterinary Science & Animal Husbandry, Mathura and local Veterinary hospital of Mathura, Uttar Pradesh, India. The approximate age of foeti were estimated by using the formula derived by Singh et al. (1979) [9] . in goat. The foeti were divided into early prenatal (0 to 50 days gestation), mid prenatal (51 to 100 days gestation) and late prenatal (101 to 147 days gestation) periods. As the separation of the pancreas from the adjacent organ was not possible before 50 days gestation, therefore from 42 and 44 days old foeti a mass of the tissue having group of the organ was collected and was fixed in neutral buffered formalin. Tissues were processed by standard protocol of tissue processing and five to six micron thick paraffin sections were obtained. The sections were stained with haematoxylin and eosin for general histoarchitecture, Wilder’s reticular stain for reticular fibres, Verhoeff’s method for elastic fibres and Masson’s trichome stain for collagen fibres (Luna, 1968) [7] . The micrometric observations were conducted with the help of computerized Motic Image Pluse 2.0 software. For each micrometric parameter 10 readings were taken at different places in the same slide. Results Early Prenatal Stage The stained serial sections of 42 days old foetus showed that the primordium of foetal goat