_____________________________________________________________________________________________________ *Corresponding author: E-mail: ekramzakaria2020@gmail.com; Journal of Advances in Medicine and Medical Research 33(9): 87-97, 2021; Article no.JAMMR.67792 ISSN: 2456-8899 (Past name: British Journal of Medicine and Medical Research, Past ISSN: 2231-0614, NLM ID: 101570965) Clinical and Biochemical Predictors of Endothelial Dysfunction in Egyptian Adolescents with Type 1 and those with Type 2 Diabetes Ekram Hamed Zakaria 1* , Medhat Abd Elmaged Ghazy 1 , Wesam Salah Mohamed 2 and Nesreen Ahmed Kotb 1 1 Internal Medicine Department, Faculty of Medicine, Tanta University, Tanta, Egypt. 2 Clinical Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt. Authors’ contributions This work was carried out in collaboration among all authors. Author EHZ performed the statistical analysis, wrote the protocol, and wrote the first draft of the manuscript. Authors MAEG and WSM managed the analyses of the study. Author NAK designed the study managed the literature searches. All authors read and approved the final manuscript.”All authors read and approved the final manuscript. Article Information DOI: 10.9734/JAMMR/2021/v33i930903 Editor(s): (1) Dr. Sevgul Donmez, Mugla Sitki Kocman University, Turkey. Reviewers: (1) Ahmed esmael, Mansoura University, Egypt. (2) Winston Isio Boff Pereira De Souza, Institute of Children with Diabetes, Brazil. Complete Peer review History: http://www.sdiarticle4.com/review-history/67792 Received 13 February 2021 Accepted 23 April 2021 Published 27 April 2021 ABSTRACT Aims: Since endothelial dysfunction precedes clinically significant diabetic vascular complications, circulating endothelial progenitor cells (EPCs) have generated interest as a biomarker of endothelial function and are considered a mirror for endogenous vasculo-regenerative capacity. So we aimed to assess EPCs count in adolescents with type 1 diabetes mellitus (T1DM) in comparison to those with type 2 diabetes mellitus (T2DM) and extend these findings to assess their relationship to other clinical and biochemical risks of endothelial dysfunction. Patients and Methods: Fifty Egyptian adolescents were included in this study, 20 with T1DM, 20 T2DM and 10 healthy control subjects. Patients are recruited from Diabetes and Endocrinology Unit, outpatient clinic of internal medicine department Tanta University Hospital, in the period from 2017 to 2019. EPCs count was determined by Flowcytometry, anthropometric measurements and laboratory investigations were done for fasting and 2-hours post-prandial blood glucose, serum Original Research Article