Chirurgia (2015) 110: 43-48 No. 1, January - February Copyright© Celsius Rezumat Fracturi osoase la bolnavii de cancer mamar cu metastaze osoase izolate Scop: Sã analizãm incidenåa fracturilor osoase la pacientele cu cancer mamar cu metastaze osoase izolate æi efectele acestora asupra supravieåuirii. Am încercat sã gãsim un rãspuns la întrebarea: “Putem prezice dezvoltarea fracturilor osoase?” Metode: Între 1993-2006, 139 de paciente cu neoplazie mamarã cu metastaze osoase izolate au fost examinate. Pacientele au fost distribuite în douã grupuri în funcåie de dezvoltarea de fracturi osoase pe os patologic. Rezultate: 41 de paciente (29.5%) au dezvoltat fracturi în pânã la 41 de luni de urmãrire. Localizãrile fracturilor pe os patologic au fost: vertebrale la 26 de paciente (63.4%), femurale la 11 paciente (26.8%), æi fracturã de æold la 4 paciente (9.8%). Frecvenåa fracturilor la paciente hormon sensibile æi hormon rezistente a fost de 31.2%, respectiv 14.3%. Rata fracturilor la 13 paciente triplu negative æi non-triplu negative a fost de 7.7%, respectiv 31.4%, (p=0.07). Valori crescute ale CA 15-3 la momentul apariåiei metastazelor la pacientele cu æi fãrã fracturi au apãrut în proporåii de 68.4%, respectiv 61.1%. Riscul de fracturã a fost de asemenea mai crescut la pacientele Her2-neu pozitive (38.7% vs. 26.5%). În timp ce incidenåa fracturilor în asociere cu unul din factorii menåionaåi mai sus a fost de 22.2%, aceasta a crescut la 36.1% în prezenåa a doi sau 3 factori (p=0.13). Supravieåuirea medie a pacientelor cu æi fãrã fracturi a fost de 48, respectiv 39 de luni (p= 0.65). Concluzie: Sensibilitatea hormonalã, nivelul crescut de CA 15-3 æi statusul Her2-neu pozitiv sunt factori de risc slab pentru apariåia fracturile osoase. Supravieåuirea nu a fost diferitã la pacientele cu fracturi osoase faåã de cele fãrã. Cuvinte cheie: cancer mamar, fracturã osoasã, metastaze osoase, evenimente scheletale, supravieåuirec Abstract Aim: To analyse the incidence of bone fracture of breast cancer patients with isolated bone metastasis and its effect on survival. We tried to find an answer to the question of “Can the development of bone fracture be predicted?” Methods: Between 1993-2006, 139 breast cancer patients with isolated bone metastasis were examined. Patients were divided into two groups depending on the development of pathologic bone fracture. Results: Fractures were developed in 41 patients (29.5%) within 41 months of follow-up. The locations of pathologic bone fracture were vertebral fracture in 26 patients (63.4%), femur fracture in 11 patients (26.8%), and hip fracture in four patients (9.8%). Fracture rates in hormone sensitive and resistant patients were 31.2% and 14.3%, respectively. The fracture rates in 13 triple negative and non triple negative patients were 7.7% and 31.4%, respectively (p=0.07). High CA 15-3 levels at the time of metastasis in patients with and without fractures were 68.4% and 61.1%, respectively. The risk for fracture was also high in Her2-neu positive patients Bone Fracture in Breast Cancer Patients with Isolated Bone Metastasis* C. Dibekoglu 1 , S. Turanli 2 , N. Karaman 2 , K. Caglar Ozcelik 3 , O. Erdogan 2 1 Department of General Surgery, Istanbul Florence Nightingale Hospital, Sisli, Istanbul, Turkey 2 Department of General Surgery, Ankara Oncology Education and Research Hospital, Ankara, Turkey 3 Department of General Surgery, Kazan Government Hospital, Ankara, Turkey Corresponding author: Sevim Turanli, MD Ankara Oncology Education and Research Hospital, Department of General Surgery 06200 Ankara/Turkey E-mail: turanlisevim@hotmail.com *This article was presented in European Society for Surgical Research 2013