Jurnal Kedokteran dan Kesehatan Indonesia Indonesian Journal of Medicine and Health Journal homepage : www.journal.uii.ac.id/index.php/JKKI ABSTRACT ARTICLE INFO Formulation of chewable lozenges of som jawa (Talinum paniculatum (Jacq.) Gaertn) leaves extract applied for Candida albicans topical infection Hanny Setyowati* 1 , Wahyuning Setyani 2 1 Department of Research and Development, Borobudur Natural Industry, Semarang 2 Faculty of Pharmacy, Sanata Dharma University, Yogyakarta *Corresponding author: hannytan18@gmail.com Keywords: Som Jawa (Talinum panicula- tum (Jacq.) Gaertn), antifungal, chewable lozenges DOI: 10.20885/JKKI.Vol10.Iss1.art4 Original Article History: Received: May 18, 2018 Accepted: April 7, 2019 Online: April 30, 2019 Copyright @2019 Authors. This is an open access article distributed under the terms of the Creative Commons At- tribution-NonCommercial 4.0 International Licence (http:// creativecommons.org/licences/ by-nc/4.0/). 14 Background: The bioactive compounds of Som Jawa (Talinum paniculatum (Jacq.) Gaertn) have many variations;one of them is flavonoid. This compound has antifungal activity towards Candida albicans, which the leading cause of topical infection. Chewable lozenges are one of the novel methods of delivering drugs for local action, especially in the mouth. Objective: To formulate chewable lozenges from Som Jawa leaves extract and evaluate their active substances. Methods: Extraction was done by rmaceration method with ethanol. The extract was evaporated using a rotary evaporator, then followed by a phytochemical investigation to express the active ingredients inside extract. Colour test was used to identify active ingredients. Som Jawa leaves extract was then formulated into chewable lozenges. Testing of physical properties of the chewable lozenges includes organoleptic test, weigh uniformity, hardness, elasticity, friability, chewiness and moisture content. Antifungal activity was tested by using a diffusion method. Result: Som Jawa leaves extract with the concentration of 50% can inhibit the growth of Candida albicans with inhibition zone diameter of 22.69 mm. The organoleptic test resulted that the dosage is odourless, brown, and chewy. Weigh uniformity resulted that all lozenges were meet the British Pharmacopoeia range with the CV < 5%. The hardness test resulted for approximately of 0.2732 Kgf. The average of elasticity, friability, and chewiness respectively was 0.0826 Kgf, 6.046 mm, and 0.4998 Kgf.mm. Conclusion: This formula chewable lozenge was potential as alternative herbal medicine for topical infection. Latar Belakang: Kandungan senyawa aktif daun Som Jawa (Talinum paniculatum (Jacq.) Gaertn) sangat beragam, salah satunya flavonoid. Senyawa flavonoid memiliki aktivitas antijamur terhadap Candida albicans, yang merupakan penyebab utama infeksi topikal. Sediaan chewable lozenges adalah salah satu metode penghantaran senyawa aktif yang bekerja secara lokal, terutama di dalam mulut. Tujuan: Penelitian ini bertujuan untuk membuat chewable lozenges dari ekstrak daun Som Jawa dan menelusuri aktivitas senyawanya. Metode: Ekstraksi dilakukan dengan metode remaserasi dengan etanol. Ekstrak tersebut diuapkan dengan rotary evaporator, kemudian diuji secara fitokimia untuk mengetahui kandungan senyawa aktif di dalam ekstrak. Identifikasi warna digunakan sebagai penanda adanya kandungan senyawa tertentu. Ekstrak daun Som Jawa kemudian diformulasikan dalam sediaan chewable lozenges. Pengujian karakteristik fisik dari chewable lozenges, meliputi organoleptik, keseragaman bobot, kekerasan, elastisitas, kekenyalan, dan kandungan air. Pengujian aktivitas antijamur dilakukan dengan metode difusi.