Conclusion: The ES after PES implantation was associated with diabetes, positive remodeling of the lesion and smaller luminal area of distal 1 mm stent after PCI. AS-199 Angioscopic Findings of Biodegradable Polymer-Coated Biolimus A9-Eluting Stent Implantation: Comparison With Sirolimus- Eluting Stent. Masaki Awata, Masaaki Uematsu, Fusako Sera, Takayuki Ishihara, Tetsuya Watanabe, Masashi Fujita, Toshinari Onishi, Osamu Iida, Yoshio Ishida, Shinsuke Nanto 1 , Seiki Nagata. Kansai Rosai Hospital Cardiovascular Center, Amagasaki, Japan; 1 Osaka University Graduate School of Medicine, Suita, Japan. Background: Second-generation drug-eluting stents are expected to show better arterial repair than older drug-eluting stents. We angio- scopically compared biodegradable polymer-coated biolimus A9-elut- ing stent (BES) and durable polymer-coated sirolimus-eluting stent (SES) to explore differences in arterial repair. Methods: Angioscopy was performed 9  1 month after 15 BES and 16 SES implanted initially in the native coronary artery. Hetero- geneity of the neointimal coverage (NIC) as well as the dominant NIC grade was examined. NIC was defined as: grade 0 = fully visible struts; grade 1 = struts bulged into the lumen, but covered; grade 2 = embedded, but translucent struts; grade 3 = invisible struts. Heteroge- neity was judged when the NIC grade variation 1. Thrombi and yellow plaques were also explored. Results: In-stent late loss (0.06  0.23 vs. 0.07  0.18 mm, p=0.80), and dominant NIC grade (1.5  0.8 vs. 1.3  0.7, p = 0.45) were similar in BES and in SES. Within the stents, NIC was more heterogeneous in SES than in BES (p = 0.035). Eighty % of BES showed homogeneous NIC, while 56 % of SES had heterogeneous NIC. Thrombi were detected in 3 BES and 5 SES (p = 0.69). Both stents commonly revealed yellow plaques (80% in BES vs. 69% in SES, p = 0.69). Conclusion: BES showed extremely limited late loss similarly to SES. NIC was strongly inhibited; thrombus adhesion and yellow plaques were similarly observed as in SES. Nonetheless, the NIC with BES was more homogeneous than that with SES. Biodegradable poly- mer-coated BES may have an advantage in acquiring homogeneous NIC. AS-200 Patency of Implanted Stents in Bangladeshi Population- A Randomized Study. Shams Munwar, AHM Waliul Islam, Shahabuddin Talukder, AQM Reza, Azfar Hossain Bhuiyan, Tamzeed Ahmed. Apollo Hospitals Dhaka, Dhaka, Bangladesh. Background: Nature of coronary artery disease (CAD) in Bangladeshi population is known to be diffuse with small caliber artery. Aim of this study was to assess primarily the stent patency in Bangladeshi popu- lation and to compare if DES is superior to BMS in the population of this underdeveloped region. The other aim was to find out the causative factors for ISR and future strategy of stenting either to reduce or to prevent ISR in patients with CAD. Methods: Patients were randomized, who underwent coronary an- giogram at our center or at different center of the city for further evaluation of their previous PTCA in the 3-36 months preceding the study. Total 349 patients (male: 284, Female: 65) were included in this study. Mean age were for Male: 59 yrs, for Female: 55 yrs. Associated CAD risk factors were Dyslipidemia, High Blood pressure, Diabetes Mellitus, Positive FH for CAD and Smoking. Results: Our results show that, among the total studied population 81.4% (284) were male and 18.6% (65) were female. Risk factors in the study group: 80% (279) were Hypertensive, 86% (300) were dyslipi- demic, 77% (269) patients were Diabetic, 38% (109) were (all male) smokers and 15.5% (54) were having positive FH for CAD, 0.5%(2) were hypothyroid. Total 523 stent was deployed in 485 vessel. Com- mon stented territory were; LAD 47% (228), RCA 29% (140) and LCX 24% (117). Total stent in LAD were 244 (46.6%), RCA 155 (29.6%) and LCX 124 (23.7%). Multiple stent in LAD, LCX and RCA were 16, 9 and 13 patients respectively. Stent used were; BMS: 279(53.3%) and DES, 244(46.6%). Re-look Coronary Angiogram (CAG) revealed in BMS treated patient had 53% (62), 66%(39) and 52.8% (47) stent patency and 24.8% (29), 25.4% (15) and 28.1% (25) developed signif- icant ISR, respectively in LAD, LCX and RCA territory after an average follow-up of 4.2 yrs. On the contrary, DES treated patient had 73% (81), 81%(47), 62%(31) stent patency and 15.3%(17), 13.7%(8) and 25%(14) developed significant ISR, respectively in LAD, LCX and RCA territory after an average follow-up period of 2.6 yrs. Among, the DES, Sirolimus 73.6%(89) was more patent than Paclitaxel eluting stent 71% (49). Everolimus, Zotarolimus and Biolimus were also showed more patency. But, in this regard, patient number were small. Conclusion: Our study has revealed that PCI with stent has in- creased event free post PCI stage with the reduction of ISR on an average follow-up periods of 3.5  2.5 yrs. Drug eluting stent showed better patency than BMS irrespective of stented coronary arterial ter- ritory in Bangladeshi population. Dyslipidemia and Hypertension along with obesity, smoking are possible key risk factor in the development of ISR. AS-201 Comparison of Clinical Outcome of In-Stent Restenosis: Drug- Eluting Stent vs Bare Metal Stent. shimpei Fujita. Iwakuni clinical center, Iwakuni, Japan. Background: The outcome of ISR after bare metal stent (BMS) has been evaluated demonstrating the usefulness of drug eluting stent (DES) for the prevention of re-ISR; however, the outcome of ISR after DES has not been fully evaluated. In this study, we evaluated whether the outcome of ISR is different between lesions originally treated with BMS and DES. Methods: We examined 72 patients and 81 lesions with ISR lesions. Originally, forty-seven lesions were treated with BMS (ori-BMS group) and 34 lesions were treated with DES (ori-DES group). Pattern of ISR was more severe in ori-BMS than in ori-DES (diffuse/focal, ori-BMS vs ori-DES=70/30% vs 45/55%, p=0.028). Results: During the follow-up period of 362 days, the target lesion revascularization (TLR) rate was greater in ori-DES group than ori- BMS group (9% vs 32%, p=0.006). In lesions treated with DES, the TLR rate was similar between ori-BMS and ori-DES (5% vs 16%, p=0.15); however, among lesions treated with POBA, the TLR rate was significantly greater in ori-DES group than in ori-BMS group (25% vs 78%, p=0.03). Conclusion: Incidence of re-ISR was higher in the lesions originally treated with DES compared with lesions originally treated with BMS. Use of DES may be better than POBA for prevention of re-ISR, especially in lesions originally treated with DES. AS-202 Clinical Efficacy and Safety of PresillionTM Plus Cobalt Chromium Stents in Acute Coronary Syndrome. Hee Hwa Ho, Kwok Kong Loh, Yau Wei Ooi, Chun Pong Wong, David Foo, FH Jafary, Paul Ong. Tan Tock Seng Hospital, Singapore, Singapore. The American Journal of Cardiology APRIL 27–29, 2011 ANGIOPLASTY SUMMIT ABSTRACTS/Poster 75A P O S T E R A B S T R A C T S Wednesday, April 27 - Friday April 29, 2011 (Poster Abstract Zone)