Röhling M et al. Impaired Lung Function in Recent Type 2 Diabetes Mellitus… Exp Clin Endocrinol Diabetes 2018; 126: 584–589 Thieme Article Thieme Röhling Martin et al. Metabolic Determinants of Im- paired … Exp Clin Endocrinol Diabetes 2018; 00: 00–00 Metabolic Determinants of Impaired Pulmonary Function in Patients with Newly Diagnosed Type 2 Diabetes Mellitus Authors Martin Röhling 1, 2, 3 , Dominik Pesta 1, 2 , Daniel F. Markgraf 1, 2 , Klaus Strassburger 2, 4 , Birgit Knebel 2, 5 , Volker Burkart 1, 2 , Julia Szendroedi 1, 2, 6 , Karsten Müssig 1, 2, 6 * , Michael Roden 1, 2, 6 * , for the GDS study group # Afliations 1 Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany 2 German Center for Diabetes Research (DZD), München- Neuherberg, Germany 3 West-German Center of Diabetes and Health, Düsseldorf Catholic Hospital Group, Düsseldorf, Germany 4 Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany 5 Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany 6 Divison of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany Key words diabetes complications, lung, single nucleotide polymor- phisms, HbA1c received 11.12.2017 revised 11.06.2018 accepted 04.07.2018 Bibliography DOI https://doi.org/10.1055/a-0653-7135 Published online: 24.8.2018 Exp Clin Endocrinol Diabetes 2018; 126: 584–589 © J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York ISSN 0947-7349 Correspondence Prof. Dr. Karsten Müssig Division of Endocrinology and Diabetology Medical Faculty, Heinrich Heine University, Düsseldorf c/o German Diabetes Center at Heinrich Heine University Auf dem Hennekamp 65 40225 Düsseldorf Germany Tel.: + 49/211/3382 218, Fax: + 49/211/3382 690 karsten.muessig@ddz.uni-duesseldorf.de Table S1, S2, S3 Online content viewable at: https://doi.org/10.1055/a-0653-7135 ABStRAct Aims Impaired lung function associates with deterioration of glycemic control and diabetes-related oxidative stress in long- standing type 2 diabetes. We hypothesized that recent-onset type 2 diabetes patients exhibit abnormal pulmonary function when compared to glucose-tolerant controls and that the fre- quencies of single-nucleotide polymorphisms (SNPs), known to associate with lung dysfunction, are diferent between both groups. Methods Type 2 diabetes patients with a known disease dura- tion < 1 year (n = 34) had similar age, sex distribution and BMI as overweight controls (n = 26). Lung function was assessed by spirometry comprising predicted forced vital capacity (FVC %), predicted forced expiratory volume in one second (FEV1 %) and the FEV1/FVC ratio. Multivariable linear regressions were per- formed to investigate group diferences, which were adjusted for potential confounders such as age, sex, BMI, height and smoking status. SNP genotyping was conducted using real- time polymerase chain reaction-based allelic discrimination. Results Patients with type 2 diabetes had lower FEV1 %, FEV1/ FVC and VO 2max (all p < 0.05). Among patients with type 2 dia- betes, FEV1 % correlated positively with VO 2max (r = 0.40, p < 0.05) and FEV1/FVC correlated negatively with HbA 1c (r = − 0.49, p < 0.01). Regression analyses across the whole co- hort indicated that the group diferences in FEV1/FVC can be explained by the confounding efect of HbA 1c . The frequencies of the SNPs rs1042713, rs1079572, rs11172113, rs12504628, rs1422795, rs1481345, rs2235910, rs2277027, rs2284746, rs4341, rs7068966, rs925284, rs993925 and rs3824658 did not difer between both groups. Conclusions Recent-onset type 2 diabetes patients exhibit reductions in features of pulmonary function, which might be at least in part resulting from glucotoxicity. * Equal contribution. # The GDS Group consists of A.E. Buyken, J. Eckel, G. Geerling, H. Al-Hasani, C. Herder, A. Icks, J. Kotzka, O. Kuss, E. Lammert, D. Markgraf, K. Müssig, W. Rathmann, J. Szendrödi, D. Ziegler and M. Roden (speaker). 584 This document was downloaded for personal use only. Unauthorized distribution is strictly prohibited.