83 April 2018, Volume 4, Issue 2, Number 13 Review Paper: Effects of Estrogen and Progesterone on Different Immune Cells Related to Multiple Sclerosis Aryan Rafee Zadeh 1* , Keyvan Ghadimi 1 , Banafsheh Mohammadi 2 , Hamidreza Hatamian 3 , Seyed Navid Naghibi 4 , Ali Danaeiniya 5 1. Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran 2. Gynecologis, Department of Gynecology and Obsetrics, School of Medicine, Ahvaz Jondishapur University of Medical Sciences, Ahvaz, Iran 3. Department of Neurology, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran 4. Kashani Comprehensive Epilepsy Center, Kashani Hospital, Department of Neurology, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran 5. MSc. in Physiology, Department of Biology, Isfahan Payam-e-Noor University, Isfahan, Iran * Corresponding Author: Aryan Rafee Zadeh, MD Address: Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Tel: +98 (938) 068 6777, Fax: +98 (31) 37323079 E-mail: rafeezadeh.a@gmail.com Multiple Sclerosis (MS) is a chronic autoimmune disease of young adults with an unknown etiology, but cellular immune responses and infammation has a pivotal role in this regard. The higher incidence of MS among women indicates the possible involvement of female sex hormones on the disease course. Progeserone and esrogen are the mos important sexual hormones in women. They exert diferent immunomodulatory efects through both nuclear and membrane associated receptors present in diferent immune cells. The immunological efects include shifting the immune response towards Th2, simulating Treg production, inhibiting pro-infammatory cytokine production, prohibiting cell migration into Central Nervous Sysem (CNS), suppressing proinfammatory immune cells, sabilizing the neuronal environment, and promoting neuronal survival, all of which might ameliorate the condition in women sufering from MS. Some clinical trials have reported a correlation between the use of Oral Contraceptives (OCs), which contain esrogen and progeserone, and MS among women. Some of these sudies show a positive efect of OC usage on the onset and severity of the disease while others have found no signifcant impact. In this review, we collected articles published between 1995 and 2017 from PubMed Central and Google Scholar for evaluating efects of esrogen and progeserone on diferent immune cells related to MS. Keywords: Multiple Sclerosis, Esrogen, Progeserone, Immune cells A B S T R A C T Article info: Received: 30 Oct 2017 First Revision: 10 Nov 2017 Accepted: 08 Feb 2018 Published: 01 Apr 2018 Bullet Points: • ٍEstrogen and progesterone both have affect on cellular immunity in MS. • The role of estrogen and progesterone in MS can be considered as a potential therapeutic opportunity. Citation: Rafee Zadeh A, Ghadimi K, Mohammadi B, Hatamian H, Naghibi SN, Danaeiniya A. Efects of Esrogen and Progeser- one on Diferent Immune Cells Related to Multiple Sclerosis. Caspian J Neurol Sci. 2018; 4(2):83-90. Running Title: Esrogen and Progeserone and Diferent Immune Cells and MS : Use your device to scan and read the artcle online Caspian Journal of Neurological Sciences "Caspian J Neurol Sci" Journal Homepage: http://cjns.gums.ac.ir Funding: See Page 43 Copyright: The Author(s)