ISSN: 2321-5674(Print) ISSN: 2320 – 3471(Online) Samaresh Pal Roy et.al Indian Journal of Research in Pharmacy and Biotechnology Volume 1(3) May-June 2013 Page 440 EVALUATION OF ANTI-ULCER EFFECTS OF ETHANOLIC EXTRACT OF DELONIX REGIA FLOWER Samaresh Pal Roy* 1 , Kamlesh Prajapati 1 , Ramji Gupta 2 , Dipanwita Bhadra 4 , Nikunj Patel 1 , Archana Batiwala 1 , Gautam Sonara 1 , Neerav Gheewala 1 , T. Kannadasan 3 1. Department of Pharmacology, Shree Dhanvantary Pharmacy College, Kim, Surat, Gujarat, India 2. Shree Dhanvantary Pharmaceutical Analysis and Research Centre, Kim, Surat 3. Anna University of Technology, Coimbatore, Tamilnadu 4. PDL Dept. Alkem Laboratory Limited, Amulya, Daman *Corresponding author: Email: samareshproy@gmail.com, Mobile: +919377077712 ABSTRACT Ulcer is one of the most common disorder in the world. The available antiulcer drug in the market have different side effect. So the people move to herbal drug for a better result and lesser side effect. Delonix regia is a plant from the family leguminosae is extensively available in the word. The earlier researcher found that the plant contain the chemical constitutent like tannin, saponin, flavonoid, so it have a good antioxident property. So, this study is planned recurred the antiulcer activity by ethanolic extract of the different doses (100mg/kg, 200mg,kg & 400mg/kg) of the flower of Delonix regia (EEDRF) on ethanol induced ulcer model in experimental rat whereas lansoprazole (8mg/kg) was taken as an standard drug. It has been found that the extract shows significant antiulcer activity in a dose dependent manner. The protection of ulcer may due to the presence of antioxidant principles present in the plant. Keywords: Delonix regia, Antiulcer, Ethanol 1. INTRODUCTION Gastric ulcer, the most common disorder of GIT has multifunctional causes in its pathophysiology. The pathophysiology of peptic ulcer has been centralized on an imbalance between aggressive and protective factors in the stomach such as acid-pepsin secretion, mucosal barrier, mucus secretion, blood flow, cellular regeneration, prostaglandins and epidermal growth factors. Although hospital admission for uncomplicated peptic ulcers in developed countries had begun decrease, there was a striking rise in admission for ulcer haemorrhage and perforation among elderly people. This increase has been attributed to the increased use of non-steroidal anti- inflammatory drugs (NSAIDs), alcoholic beverages, cigarettes and Helicobacter pylori infections. It is now considered to be one of the modern age epidemics affecting nearly 10% of world population during last decade have offered new insights in the therapy and prevention of peptic ulceration. Plants provide an alternative strategy in search for new drugs. There is a rich abundance of plants reputed in traditional medicine known to possess antiulcer properties. It is likely that plants will continue to be a valuable source of new molecules which may, after possible chemical manipulation, provide new and improved antiulcer drugs. Borrelli and Izzo reveal the extensive variety of chemical compounds isolated from medicinal plants with antiulcer activity. Literature search revealed that herbs rich in flavonoids show several biological activities including antiulcerogenic activity. This is an important reason to investigate antiulcer effects in medicinal plants with traditional use in gastric diseases. Delonix regia is a plant from the family leguminosae, is extensively cultivated in most regions of the world. The flowers of Delonix regia are commonly used as an antibacterial, analgesic, antiulcer, anti- inflammatory and antimicrobial. Reports indicate that pharmacological activities of Delonix regia flowers include anti-inflammatory and analgesic (Ahmad & Aqil., 2003), antimicrobial, broad spectrum antibacterial and antifungal activities.Wijayasirivardena et al 2009 reported the plant possess antiinflammatory activity. Muruganathan et al. 2011 reported that the bark of Delonix regia showed significant anti-inflammatory and anti-arthritic activity. Pradeepa et al. 2012 reported the leaf extract of Delonix regia showed antinociceptive activity. The plant has been claimed to be useful as antioxidant (Aquil et al., 2006), larvicidal (Chockalingam et al., 1990), antibacterial, antifungal (Ahmed et al., 2003), anti-inflammatory, analgesic (Muruganandam et al., 2000), nutritional (Grant et al., 1991), antimalerial (Ankrah et al., 2003), antiperiodic, febrifuge, emetic, CNS depressant (Rastogi et al., 1993) and antirheumatic (Khare et al., 2007). Its aqueous and alcoholic extracts were active against roundworm. The bark contains leucocyanidin, lupeol, tannin, -sitosterol and free OH-proline as