Research Article QualityofLifeandRelatedParaclinicalFactorsinIranian Patients with Transfusion-Dependent Thalassemia Mehran Khodashenas, 1 ParhamMardi , 1 Nooshin Taherzadeh-Ghahfarokhi, 1 Bahareh Tavakoli-Far, 2,3 Mahnaz Jamee, 1 andNiloofarGhodrati 4 1 Student Research Committee, Alborz University of Medical Sciences, Karaj, Iran 2 Dietary Supplements and Probiotic Research Center, Alborz University of Medical Sciences, Karaj, Iran 3 Department of Physiology and Pharmacology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran 4 Hematologist-Oncologist,FacultyMember,DepartmentofInternalMedicine,AlborzUniversityofMedicalSciences,Karaj,Iran Correspondence should be addressed to Niloofar Ghodrati; niloofar.ghodrati1@gmail.com Received 29 May 2021; Accepted 29 July 2021; Published 18 August 2021 Academic Editor: Amir Radfar Copyright © 2021 Mehran Khodashenas et al. is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. alassemia is one of the most common genetic hematologic disorders in the world. Despite outstanding achievements in prenatal diagnosis and a decrease in the number of patients, thalassemia is still a significant issue in most parts of the world, especially in the Mediterranean countries. Understanding the factors associated with this condition is crucial to help clinicians and policymakers provides social and medical support for patients to facilitate their lives. is study aims to appraise the quality of life (QoL) and its related paraclinical factors in Iranian transfusion-dependent thalassemia patients. MethodsandMaterials. is study is a cross-sectional study performed in the thalassemia clinic of Imam-Ali Hospital, Karaj, Iran. e demographic, clinical, and laboratory data of 100 patients with transfusion-dependent thalassemia were recorded. e patients’ QoL was measured by the World Health Organization Quality of Life Instruments Brief (WHOQOL-BREF) version questionnaire. e results were analyzed using SPSS software. Results. is study demonstrated that all four features of life are influenced in transfusion-dependent thalassemia patients. Also, higher educational status and lower serum ferritin levels were associated with better scores in assessing the QoL. On the other hand, an elevated level of AST (aspartate transaminase), ALT (alanine transaminase), and FBS (fasting blood sugar) are associated with lower scores. Conclusion. All features of QoL are correlated to the patients’ laboratory findings. Our data suggest that managing patients’ laboratory indices is attributed to their higher QoL. We also suggest regular screening of patients’ QoL to manage disease complications more efficiently. 1.Introduction alassemia is an inherited blood disorder and one of the most common monogenic diseases in the world. It has been a critical health issue in the Mediterranean region, Middle East, Southeast Asia, and India [1, 2]. Overall, approximately 200 million people are affected globally [3]. Recent studies suggest that despite improvements in prenatal diagnosis, between 300,000 and 400,000 neonates are born with thalassemia every year, most of them in developing countries [4–7]. In Iran, the prevalence of thalassemia ranges from 1% to 10% in various parts of the country [1, 8]. It should be noted that about two million thalassemia carriers are reg- istered in the country, making the disease a significant public health issue [9, 10]. alassemia is more prevalent in the northern and southern parts of the country [10, 11]. ere are four types of thalassemia: α, β, c, and δ thalassemia. ß-alassemia is a chronic autosomal recessive disorder in which ß-globin chain synthesis is decreased or absent. ere are about 200 mutations associated with the thalassemia phenotype [12, 13]. In ß-thalassemia minor, the synthesis of hemoglobin A (α2, β2) decreases due to a single mutation in ß-gene, leading to red blood cell (RBC) de- struction. While some ß-thalassemia patients are usually Hindawi Journal of Environmental and Public Health Volume 2021, Article ID 2849163, 6 pages https://doi.org/10.1155/2021/2849163