Research Article Synthesis, Characterization, and BSA-Binding Studies of Novel Sulfonated Zinc-Triazine Complexes Nalin Abeydeera, 1 Inoka C. Perera, 2 and Theshini Perera 1 1 Department of Chemistry, University of Sri Jayewardenepura, Nugegoda, Sri Lanka 2 Department of Zoology and Environmental Science, University of Colombo, Colombo, Sri Lanka Correspondence should be addressed to eshini Perera; theshi@sjp.ac.lk Received 18 August 2017; Revised 9 November 2017; Accepted 28 November 2017; Published 18 February 2018 Academic Editor: Francesco Paolo Fanizzi Copyright © 2018 Nalin Abeydeera et al. is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Four Zn(II) complexes containing a pyridyl triazine core (L1 � 3-(2-pyridyl)-5,6-di(2-furyl)-1,2,4-triazine-5′,5″-disulfonic acid disodium salt and L2 � 3-(2-pyridyl)-5,6-diphenyl-1,2,4-triazine-4′,4″-disulfonic acid sodium salt) were synthesized, and their chemical formulas were finalized as Zn(L1)Cl 2 ]·5H 2 O·ZnCl 2 ( 1 ), Zn(L1) 2 Cl 2 ]·4H 2 O·2CH 3 OH (2), Zn(L2)Cl 2 ]·3H 2 O·CH 3 OH (3), and Zn(L2) 2 Cl 2 ](4). The synthesized complexes are water soluble, making them good candidates for biological applications. All four complexes have been characterized by elemental analysis and 1 H NMR, IR, and UV-Vis spectroscopy. e IR stretching frequency of N�N and C�N bonds of complexes 1–4 have shifted to lower frequencies in comparison with free ligands, and a bathochromic shift was observed in UV-Vis spectra of all four complexes. The binding studies of ligands and complexes 1–4 with bovine serum albumin (BSA) resulted binding constants (K b ) of 3.09 × 10 4 M −1 , 12.30 × 10 4 M −1 , and 16.84 × 10 4 M −1 for ferene, complex 1 , and complex 2, respectively, indicating potent serum distribution via albumins. 1. Introduction e potential use of zinc complexes as antidiabetic insulin mimetics 1], antimicrobial 2], and anticancer agents 3] have garnered a renewed interest in such complexes among other applications, such as serving as tumor photo sensitizers 4], radioprotective agents 5], and antidandruff agents (Zn pyrithione-ZPT) 6]. Our interest in sulfa drug moieties has been fueled by the fact that they possess a wide range of pharmaceutical applications 7]. Of par- ticular interest are 1,2,4-triazine derivatives because they have been reported to possess many biological activities such as kinase inhibition 8], antihypertensivity 9], an- timicrobial 10], anticancer 11], anti-HIV 12, 13], and anti-inflammatory activities 8]. Novel polyanionic sulfonated aromatic synthetic plati- num chelates were preliminarily evaluated for their HIV-1 virucidal activity, due to the presence of sulfonated aromatic groups and metals in the most active members 14, 15]. Furthermore, we recently reported that rhenium tricarbonyl complexes of ferene and ferrozine have exhibited the po- tential to be used as biological imaging agents 16]. (Chemical structures of ferene and ferrozine are illustrated in Figure 1.) However, to the best of our knowledge, no reports exist of zinc complexes of sulfonated 1,2,4-triazine derivatives. It is noteworthy that although zinc complexes bearing the 5,6-diphenyl-3, 2-pyridyl-1 2,4-triazine ligand were first synthesized more than a decade ago 17, 18], biological studies have been reported for only one such complex, albeit only recently 19]. erefore, our goal has been to synthesize zinc complexes bearing sulfonated pyridyl tri- azine derivatives and to assess their interaction with bi- ological targets. Being the most abundant protein in blood, serum al- bumin maintains the colloid osmotic pressure, while playing a major role in transport and sustained release of many biomolecules such as steroids, fatty acids, and hormones. Serum albumin also serves as a carrier protein for drug molecules 20]. Small molecule interaction with serum Hindawi Bioinorganic Chemistry and Applications Volume 2018, Article ID 7563820, 7 pages https://doi.org/10.1155/2018/7563820