1 3 World J Urol DOI 10.1007/s00345-016-1942-z ORIGINAL ARTICLE Can intraperitoneal bupivacaine decreases pain in patients undergoing laparoscopic live donor nephrectomy? A randomized control trial Ankush Jairath 1 · Arvind Ganpule 2 · Shinu Gupta 3 · Shashikant Mishra 2 · Ravindra Sabnis 2 · Mahesh Desai 2 Received: 6 July 2016 / Accepted: 20 September 2016 © Springer-Verlag Berlin Heidelberg 2016 pain scores was statistically significant (p < 0.05) at 0, 2 and 4 h. The mean dose of rescue analgesia (pentazocin, 30 mg in one vial) in group A was 33 ± 26 mg which was significantly less as compared to group B where it was 62 ± 28 mg. There was statistically insignificant difference between all cardiorespiratory factories at all-time inter- vals except for heart rate and mean blood pressure at 0 h in group A as compared to group B. Conclusions Intraperitoneal bupivacaine is a simple, safe, inexpensive method for control of postoperative pain in patients undergoing laparoscopic live donor nephrectomy. Use of the correct dose and concentration of the drug are essential for effective pain control. Keywords Laparoscopic live donor nephrectomy · Intraperitoneal · Bupivacaine · Local anesthetic Introduction Renal transplantation is the treatment of choice for the patients with end-stage renal disease [1]. Subjecting the donor to an open procedure not only increases donor’s mor- bidity in terms of increased hospital stay and large painful scar, but also discouraged potential donors. This has moti- vated the surgeons to come up with a less morbid technical alternative, the laparoscopic donor nephrectomy and better pain control measures. Laparoscopic live donor nephrec- tomy (LLDN) is now the gold standard and preferred method for kidney harvestation in renal transplant surgery. Postoperative pain is the main cause of delay in resump- tion of normal daily activity after any operative procedure. Despite better understanding of pain pathophysiology, pharmacology of analgesics and development of newer more effective analgesic techniques, many patients still Abstract Purpose To evaluate effect of intraperitoneal bupivacaine on postoperative pain in patients undergoing laparoscopic live donor nephrectomy. Methods Hundred patients undergoing laparoscopic live donor nephrectomy were included in the study and were divided randomly into two groups based on computer- generated randomization chart of fifty each. Patients were made familiar with VAS chart preoperatively. Group A received 20 mL of 0.5 % bupivacaine, while group B patients received 20 mL of 0.9 % normal saline intraperi- toneally Postoperatively, patients were assessed based on VAS and requirement of rescue analgesic, hemodynamic parameters and presence of any adverse effects. Student’s t test was used for statistical analysis. Results At all-time interval, mean pain scores were higher in group B than group A. The difference between the mean * Ankush Jairath ankushjairath@gmail.com Arvind Ganpule doctorarvind1@gmail.com Shinu Gupta shinujairath@rediffmail.com Shashikant Mishra mishra@mpuh.org Ravindra Sabnis rbsabnis@gmail.com Mahesh Desai mrdesai@mpuh.org 1 Muljibhai Patel Urological Hospital (MPUH), Dr Varendra Desai Road, Nadiad, Gujrat, India 2 Muljibhai Patel Urological Hospital (MPUH), Nadiad, India 3 Civil Hospital, Ludhiana, India