Mohammed Shukur, Omar Heshmeh, Safaa Shihabi. The Effcacy Of Adhesive Tissue Iceberg-Gluein Reducing Post-Operative Bleeding And Pain After Surgical Removal Of Impacted Lower Third Molars: A Randomized Clinical Trial. Int J Dentistry Oral Sci. 2021;8(10):4806-4811. 4806 OPEN ACCESS https://scidoc.org/IJDOS.php The Effcacy Of Adhesive Tissue Iceberg-Gluein Reducing Post-Operative Bleeding And Pain After Surgical Removal Of Impacted Lower Third Molars: A Randomized Clinical Trial Research Article International Journal of Dentistry and Oral Science (IJDOS) ISSN: 2377-8075 *Corresponding Author: Safaa Shihabi, MSc in Pediatric Dentistry, Faculty of Dentistry, Damascus University, Syria. Tel: 00963934101164 E-mail: safaa2671991@gmail.com Received: September 16, 2021 Accepted: October 10, 2021 Published: October 22, 2021 Citation: Mohammed Shukur, Omar Heshmeh, Safaa Shihabi. The Effcacy Of Adhesive Tissue Iceberg-Gluein Reducing Post-Operative Bleeding And Pain After Surgical Removal Of Impacted Lower Third Molars: A Randomized Clinical Trial. Int J Dentistry Oral Sci. 2021;8(10):4806-4811. doi: http://dx.doi.org/10.19070/2377-8075-21000974 Copyright: Safaa Shihabi © 2021. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribu- tion and reproduction in any medium, provided the original author and source are credited. Mohammed Shukur 1 , Omar Heshmeh 2 , Safaa Shihabi 3* 1 Msc student in Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, Damascus University, Syria. 2 Professor in Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, Damascus University, Syria. 3 MSc in Pediatric Dentistry, Faculty of Dentistry, Damascus University, Syria. Introduction Third molars are the most susceptible to impaction because they are the last teeth to erupt, so they do not fnd enough space to erupt [1]. Extraction of impacted third molars is the most com- mon surgical procedure in the dental clinic (Brad and Jafoo) of- ten characterized by the following period. Surgical extraction of third molars in the presence of edema, hemorrhage and pain [2] Although suturing is the common traditional method for round- ing wound edges in impacted molars, it has many disadvantages as it can cause a permanent effect of the sutures, Swelling in the wound and injury as a result of needle insertion in addition to reactions due to the presence of a foreign body, the formation of granules and isolates in tissues and infection [3]. Various alterna- Abstract Background: There is various wound closure techniques have been used in medical literatures like traditional non-absorbable sutures and advanced modalities, suchas synthetic absorbable sutures, surgical staples and tissue adhesives. Suturing has been the conventional method for approximating wound margins. However,suturing has many disadvantages leading to various alternative material closure options. This need to an interest in tissue adhesives such as new generation of cyanoacrylate which has unique properties lead us to focus on this technique in our study. Aim: Evaluation the effcacy of the adhesive tissue(iceberg-glue) in minimizing the post-operative bleeding and pain after surgical removal of impacted lower third molars. Materials and Methods: Sample size consisted of 19 patients with bilateral and symmetrical impacted lowers third molars were included in this randomized, split-mouth study. Patients with any pre-existing pathology or systemic disease were excluded. On one random side were surgically closure using silk suture (3-0) (group A), and using an adhesive tissue on the contralateral side (groupB). The comparison of the post-operative bleedingevaluation rated from (3hours, 6hours, 9hours, 12hours) post surgically, and post-operative pain evaluation in (one, third, and seven days) post surgically, the bleeding and pain assessment according to VAS scales. Result: Bleeding assessment according to Mann-Whitney U test,the outcome reveals statistically signifcant differences for adhesive group in the (3 hours, 6 hours, 9 hours) after surgery in adhesive tissue group (p<0.05) where as there is no signifcant difference in (12 hours) after surgery between two groups (p>0.05), pain assessed according to T-student test which reveals statistical signifcant differences in the one and third days post surgically for adhesive group and there is no differences in the seven days between the two groups. Conclusion: The iceberg-gluehas a signifcant and effective effect on hemostasis after surgical extraction of impacted lower molars compared with traditional suture with 3-0 silk thread. Keywords: Surgical Extraction; Adhesive Tissue; Suture-Impacted Third Molar; Bleeding; Pain.