REVIEW Local delivery of corticosteroids in clinical ophthalmology: A review Adrian T. Fung MMed FRANZCO 1,2,3 | Tuan Tran MBBS MMed 3 | Lyndell L. Lim DMedSci FRANZCO 4,5,6 | Chameen Samarawickrama PhD FRANZCO 1,3,7 | Jennifer Arnold FRANZCO 8 | Mark Gillies PhD FRANZCO 3 | Caroline Catt MMed FRANZCO 3,9 | Logan Mitchell MOphth FRANZCO 10 | Andrew Symons PhD FRANZCO 11 | Robert Buttery PhD FRANZCO 12 | Lisa Cottee MBA FRCOphth 13 | Krishna Tumuluri FRANZCO 1,2,3 | Paul Beaumont FRANZCO 13 1 Westmead Clinical School, Discipline of Clinical Ophthalmology and Eye Health, University of Sydney, Sydney, New South Wales, Australia 2 Department of Ophthalmology, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia 3 Save Sight Institute, Central Clinical School, Discipline of Clinical Ophthalmology and Eye Health, University of Sydney, Sydney, New South Wales, Australia 4 Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia 5 Centre for Eye Research Australia, Melbourne, Victoria, Australia 6 University of Melbourne, Melbourne, Victoria, Australia 7 Liverpool Clinical School, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia 8 Marsden Eye Specialists, Sydney, New South Wales, Australia 9 Children's Hospital Westmead, Westmead, New South Wales, Australia 10 University of Otago, Dunedin, New Zealand 11 Royal Melbourne Hospital, Melbourne, Victoria, Australia 12 Melbourne Retina Associates, Melbourne, Victoria, Australia 13 Eye Doctors Mona Vale, Sydney, New South Wales, Australia Correspondence Adrian T. Fung, MMed, FRANZCO, Department of Ophthalmology, Westmead Hospital, Corner of Hawkesbury and Darcy Roads, Westmead, New South Wales 2145, Australia. Email: adrian.fung@sydney.edu.au Abstract Locally administered steroids have a long history in ophthalmology for the treatment of inflammatory conditions. Anterior segment conditions tend to be treated with topical steroids whilst posterior segment conditions generally require periocular, intravitreal or systemic administration for penetration. Over recent decades, the clinical applications of periocular steroid delivery have expanded to a wide range of conditions including macular oedema from retino-vascular conditions. Formulations have been developed with the aim to provide practical, targeted, longer-term and more efficacious therapy whilst minimizing side effects. Herein, we provide a comprehensive overview of the Received: 23 July 2019 Revised: 21 November 2019 Accepted: 9 December 2019 DOI: 10.1111/ceo.13702 This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2019 The Authors. Clinical & Experimental Ophthalmology published by John Wiley & Sons Australia, Ltd on behalf of Royal Australian and New Zealand College of Ophthalmologists. 366 Clin Experiment Ophthalmol. 2020;48:366–401. wileyonlinelibrary.com/journal/ceo