CASE REPORT Papillary cystadenocarcinoma of the submandibular gland Murat U ¨ nal a, * ,O ¨ zlem Aydin b ,Yu¨celAkbas ¸ a , Yavuz Selim Pata a , Tugay C ¸evik a a Department of Otorhinolaryngology, Mersin University School of Medicine, 33079 Mersin, Turkey b Department of Pathology, Mersin University School of Medicine, 33079 Mersin, Turkey Received 7 September 2005; accepted 11 September 2005 Summary Papillary cystadenocarcinoma is an extremely rare malignant neoplasm characterized by cysts and papillary endophytic projections. It was first defined in 1991 by WHO. We presented a case of papillary cystadenocarinoma arising from the submandibular gland in a 78-year-old male patient, and discussed the clinical, histopathological and treatment features of this rare entity in the light of the cur- rent literature.  c 2005 Elsevier Ltd. All rights reserved. KEYWORDS Papillary cystadenocarcinoma; Salivary gland neoplasm Introduction Papillary cystadenocarcinoma is an extremely rare malignant neoplasm that was first defined in 1991 by WHO. 4 It has also been called malignant papil- lary cystadenoma, low-grade papillary adeno- carcinoma, or mucus-producing adenopapillary carcinoma. 2 In this article, we report an unusual case of papillary cystadenocarcinoma arising from the submandibular gland. Case report A 78-year-old male patient complaining of painless mass in the right upper neck was referred to our department. On examination, a solid 5 · 3 cm mass was palpated in the right submandibular region. The rest of the ear–nose–throat examination was normal. The patient has had a history of myelofi- brosis for 6 months and asthma for many years. Then fine needle aspiration biopsy was performed under ultrasonographic view and revealed ‘malig- nant epithelial cells’. A computed tomography re- vealed a mass lesion in the right submandibular gland without any involvement of the surrounding tissues and cervical lymph nodes. The patient underwent right total submandibular gland extirpa- tion under general anesthesia. Macroscopically, 1741-9409/$ - see front matter  c 2005 Elsevier Ltd. All rights reserved. doi:10.1016/j.ooe.2005.09.005 * Corresponding author. Address: Mersin Universitesi Tip Fakultesi Hastanesi, KBB AD, Zeytinlibahce cad., 33079 Mersin, Turkey. Tel.: +90 324 337 4300; fax: +90 324 337 4305. E-mail addresses: muunal@hotmail.com, munal@mersin. edu.tr (M. U ¨ nal). Oral Oncology EXTRA (2006) 42, 82–84 http://intl.elsevierhealth.com/journal/ooex brought to you by CORE View metadata, citation and similar papers at core.ac.uk provided by Elsevier - Publisher Connector