Sys Rev Pharm 2021;12(1):1572-1580 A multifaceted review journal in the field of pharmacy 1572 Systematic Reviews in Pharmacy Vol 12, Issue 1, January 2021 An In-Vitro Comparative Analysis on Root Canal Transportation, Centering Ability, Angle of Curvature Using XP-Endo Shaper and WaveOne Gold Rotary Systems-A CBCT Study *Asok Mathew 1 , Abdullatif Burahmah 2 , Salem Abu Fanas 3 , Okba Mahmoud 4 , Mohamed Abdullah Jaber 5 , Prabhu Manickam Natarajan 6 , Ahmed Radeideh 7 1 Clinical Assistant Professor, University of science and Technology of Fujairah, UAE. 2 Assistant Registrar, Kuwait, MOH 3 Dean, College of Dentistry, Ajman University, Ajman, UAE. 4 Assistant Professor, College of Dentistry, Ajman University, Ajman, UAE. 5 Professor, Head of Department of clinical sciences, College of Dentistry, Ajman University, Ajman, UAE 6 Associate Professor, University of science and technology of Fujairah, UAE 7 Lecturer, University of Science and Technology of Fujairah, UAE. Corresponding Author: Asok Mathew Email: drashokm@gmail.com ABSTRACT Background: In this study we highlight the difference between two recent single file endodontic systems XP-endo Shaper by FKG and WaveOne Gold by Dentsply by measuring their efficiency through assessing the centering ability, canal transportations, preparation time and changes in canal curvature on resin endodontic blocks using Cone Beam Computed Tomography. Material and Methods: Fourteen resin endodontic blocks are used for each system. The assessment was done by comparing and measuring the data collected of pre-instrumentation and post-instrumentation CBCT axial and sagittal images to assess the centering ability, canal transportation, preparation time and changes in canal curvature. These measurements were taken in 3mm ,5mm and 7 mm from the apical exit of the endodontic block used. Results: The mean Canal Transportation of XP System (Group A) in 3mm, 5mm and 7mm sections measured with values (-.5214, -.2714 and -.02140) respectively. The mean transportation of WaveOne Gold system (Group B) in 3mm, 5mm and 7mm in sections with values (-.3214, -.2571 and -.1143.) respectively, whereas the mean centering ability of XP System (Group A) in 3mm, 5mm and 7mm sections measured with values (.0714, -.6131 and -.9881) respectively. The mean transportation of WaveOne Gold system (Group B) in 3mm, 5mm and 7mm sections is given as (-.3255, -.6310 and -.6429) and there was no significant difference noted in centering ability and canal transportation between the two systems. The mean root canal preparation time showed no statistical difference between the two systems employed. There was statistical difference noted in the changes in pre- and post-curvatures of the canal between two systems studied. Conclusion: With our limitation in sample size, it was concluded that reciprocation motion in WaveOne Gold system gave better results in canal transportation and centering ability in the simulated apical part in endo-blocks than continues motion rotary preparation in XP endo shaper system. WaveOne Gold produced lesser canal transportation in the apical 3 rd while XP endo shaper produced less canal transportation and centering ability in the middle 3 rd simulated endo-blocks. Keywords: WaveOne Gold, XP Shaper, Single file system, Canal transportation, Centering ability Correspondence: Asok Mathew Clinical Assistant Professor, University of science and technology of Fujairah, UAE Email: drashokm@gmail.com INTRODUCTION For a proper and successful root canal treatment, the number of microbes needs to be reduced through different chemical and mechanical procedures. 1,2 The preparation for the root canal procedure is known to be one of the most crucial factors that have a linear relation with the efficacious disinfecting process and the consequent treatment result. The process of preparation of root canal by means of instruments made of nickel and titanium has gained popularity over the last twenty years. The root canal treatment process is one of the most significant therapies that provide help to the teeth to function properly and stay in the esthetic condition. The process of endodontic treatment is entirely concerned with the elimination of pulp present in the teeth region and the preparation of the canal for the process of obturation. 3 One of the major important stage that contributes to the treatment of the root canal is the preparation of the canal, as an outcome of the estimation of the organized procedures sequenced, which in turn help in placing the fluid of the root canal with appropriate canal covering for protection. 4 An important motive of the endodontic treatment is the debriding of the overall tissue by tightening the fluid obturation with respect to the amount of space made. 5 This target can be gained quite easily when straight and huge canals are considered, however, it becomes a tedious task when curved and dented canals have to be operated. 6 The mistakes that occur during the endodontic treatment procedures such as transportation of the apical root canal, the formation of an elbow structure in the teeth, the perforation of the strips, and lastly the damage caused to the tools and equipment used. 7 These errors caused during the dental procedures grow in number when the dentist or the operating doctor is attending a case of patients with dented and narrow canals or if the dental tools used are hard or already damaged.