International Surgery Journal | August 2020 | Vol 7 | Issue 8 Page 2485 International Surgery Journal Ahmadabadi F et al. Int Surg J. 2020 Aug;7(8):2485-2489 http://www.ijsurgery.com pISSN 2349-3305 | eISSN 2349-2902 Original Research Article Frequency, causes, and findings of brain CT scans of neonatal seizure at Ardabil City Hospital, Ardabil, Iran Farzad Ahmadabadi 1,2 , Mehrdad Mirzarahimi 1,2 *, Adel Ahadi 1,2 , Zahra Alizadeh 2 INTRODUCTION Neonatal seizures are the primary and most important signs of neural function disorders that often lead to serious neural complications. However, these disorders are predictable and manageable with suitable diagnostic and therapeutic methods. If left untreated, neonatal seizures can cause irreversible damage to the neural system and put neonates at risk of death. Furthermore, those that survive would be at risk of epilepsy, and neurological and developmental disorders. 1 Seizures are categorized as attack disorders meaning that it leads to sudden and reversible changes in the mental status and somatosensory performance of the individual. They have a repetitive nature and last from several seconds to several minutes, end quickly and return to the natural status gradually. Seizures that originate from a cerebrovascular region are called localized and those originating simultaneously from both lobes are called generalized seizures. Seizures can be categorized generalized categories including absence, tonic, clonic, petit-mal, myoclonic, atonic, and focal or partial seizures. 2 Neonatal seizures are clinically referred to the abnormal and repetitive changes that occur in the brain function in ABSTRACT Background: Neonatal seizures are the primary and most important signs of neurologic function disorders that often lead to serious complications. However, this disorder is predictable and manageable with suitable diagnostic and therapeutic methods. The aim of this study was to investigate the frequency, causes, and findings of brain CT scans of neonatal seizure. Methods: This descriptive cross-sectional study has been done on 70 neonates with seizures who hospitalized in Ardabil city hospital during 2016-2017. CT scans were done for all patients. Necessary information for each patient was recorded in a checklist including demographic data, history of diabetes mellitus, hypertension, and maternal endocrine disorders, and history of resuscitation and clinical data including type of seizure and its duration, Cause of seizure and CT scan findings (cerebral hemorrhage, local ischemic lesions, hypoxemic-ischemic encephalopathy, and anatomical cerebral malformations). Results: The mean age of neonates was 12.41±9.33 days. Of them, 61.4% were boys, 3.24% LBW and 40% were preterm at birth time. Of all neonates, 21.4% had history of seizure in their relative degree family members. Fever was the most common symptom accompanying seizures (40%). The most common form was tonic seizure (n=30, 42.9%) and its duration time was 4.99 minute. A total of 41.4% of neonates (29 cases) had abnormal CT scan reports. Hypoxic-ischemic encephalopathy (47%) was the most common findings in the CT scans of neonates with seizures. Conclusions: Results showed that, a considerable number of neonates had abnormal CT findings and the most common abnormal form was hypoxemic-ischemic encephalopathy. Keywords: CT scan, Generalized seizure, Neonates, Seizure 1 Department of Pediatrics, 2 School of Medicine, Ardabil University of Medical Science, Ardabil, Iran Received: 18 May 2020 Accepted: 04 July 2020 *Correspondence: Dr. Mehrdad Mirzarahimi, E-mail: m.mirzarahimi@arums.ac.ir Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: http://dx.doi.org/10.18203/2349-2902.isj20203227