NONSTEROIDAL ANTI-INFLAMMATORY DRUGS INHIBIT A FYN DEPENDENT PATHWAY COUPLED TO RAC AND STRESS KINASE ACTIVATION IN TCR SIGNALING Silvia ROSSI PACCANI, Laura PATRUSSI, Cristina ULIVIERI, Jaime L. MASFERRER * , Mario Milco D'ELIOS * and Cosima T. BALDARI Department of Evolutionary Biology, University of Siena, Siena, Via Aldo Moro 2, 53100 Siena, Italy; * Oncology Discovery Research, Pfizer Corporation, St. Louis, Missouri, USA; * Department of Internal Medicine and Immunoallergology, University of Florence, Viale Morgagni 85, 50134 Florence, Italy Running head : Suppression of Fyn dependent Rac/stress kinase activation by NSAID Corresponding author : Dr. Cosima T. Baldari, Department of Evolutionary Biology, University of Siena, Siena, Via Aldo Moro 2, 53100 Siena, Italy. Tel. +39-0577-234400; fax +39-0577-234476; e-mail baldari@unisi.it This work was generously supported by the Italian Association for Cancer Research (AIRC), Telethon (grant E.1161), the European Commission (QLK2-CT-2002-00620) and the University of Siena (PAR). Word count (total text/abstract) : 3841/199 Scientific Section Heading : Immunobiology Blood First Edition Paper, prepublished online October 28, 2004; DOI 10.1182/blood-2004-04-1299 Copyright © 2004 American Society of Hematology For personal use only. on April 20, 2017. by guest www.bloodjournal.org From