- 89 - 서 론 주의력결 과잉동장애(attention-deficit hyperactivity disorder, ADHD)는 주의력결, 과잉동 , 충동성을 주증상 으로 는 신경달적 증후군이 아동기에 여  습, 또래관계, 사회성, 가족관계, 정서적 안녕 등 다양 영역 에서 기능장애 야기다. ADHD 유은 령기에는 약 5%이고 성인기에는 2.5% 정도로 추정되, 1) 국내 서울지역 초등생을 대상으로  역 조사에서는 6.5%로 조사되었다 . 2) 령기 ADHD 아동의 일 차치는 약요으로, 국내에서는 methylphenidate 제제 와 atomoxetine이 가장 이 처되어 왔다 . 3) ADHD 아동의 37-85%가 청소년기와 성인기까지 증상이 지속되는 성 경 과이로, 4) 장기간 약치 유지에 따라 성장에 치 자연경과 관찰에 의한 주의력결핍 과잉행동장애 아동에서 장기간의 약물치료가 성장에 미치는 영향 염찬우 1) ·은태경 1) ·박훈섭 1) ·이규영 1) ·김의중 1) ·주은정 1) ·구영진 2) 을지대교 의과대 을지원 정신건강의교실, 1) 을지대교 의과대 을지원 정신건강의교실 소아청소년 클닉 2) A Study about Long-Term Efects of Attention-Defcit Hyperactivity Disorder Medication on Height and Weight in the Korean School-Aged Boys with Attention-Defcit Hyperactivity Disorder Based on Observation of Natural Course Chan-Woo Yeom, M.D. 1) , Tae-Kyung Eun, M.D. 1) , Hoon-Sub Park, M.D. 1) , Kyu-Young Lee, M.D., Ph.D. 1) , Eui-Joong Kim, M.D., Ph.D. 1) , Eun-Jeong Joo, M.D., Ph.D. 1) , and Young-Jin Koo, M.D., Ph.D. 2) 1) Department of Neuropsychiatry, Eulji General Hospital, Eulji University School of Medicine, Seoul, Korea 2) Department of Child and Adolescent Psychiatry, Eulji General Hospital, Eulji University School of Medicine, Seoul, Korea Objectives：This study was conducted naturalistically in order to observe the long-term effects of attention-defcit hyperactiv- ity disorder (ADHD) medications on growth rates among Korean school-aged boys with ADHD. Methods：Participants in the study were boys with ADHD aged 6 to 11 years who have taken ADHD medication, methylphe- nidate (extended release) or atomoxetine. They attended scheduled visits monthly or bimonthly for clinical assessment with mea- surement of height and weight. In this study, 35 boys with ADHD (mean age at baseline=7.90±1.77 years ; mean age at endpoint= 12.54±1.91 years) were included, with a mean follow-up period of 4.64 years (±1.62 years), ranging from 2 to 9.7 years. Height, weight, and body mass index (BMI) measurements were converted to “age-corrected Z-scores” using data from Growth Charts provided by the Korean Center for Disease Control and Prevention from 2007. Results：Age-corrected endpoint growth parameters (height, weight, BMI Z-scores) did not differ signifcantly from the baseline values (height t=0.027 ; weight t=-0.61 ; BMI t=-1.86, in paired t-test). Especially high correlation was observed between the baseline and endpoint height Z-scores (r=0.876, p<.001), for which the coeffcient of determination r 2 was 0.767, meaning that the amount of variability in endpoint height Z-scores explained by the baseline height Z-scores was 76.7%. Conclusion：Our results suggested that the long-term effects of ADHD medications on growth parameters to be tolerable in Korean school-aged boys with ADHD. KEY WORDS：ADHDㆍPharmacotherapyㆍLong-Term Effects on Growth. 접수완료：2014년 2월 17일 / 수정완료：2014년 5월 23일 심사완료：2014년 5월 24일 Address for correspondence：Young-Jin Koo, M.D., Ph.D., Department of Child and Adolescent Psychiatry, Eulji General Hospital, Eulji University School of Medi - cine, 68 Hangeulbiseok-ro, Nowon-gu, Seoul 139-872, Korea Tel ： +82.2-970-8708, Fax ： +82.2-949-2356 E-mail ： kdockr@gmail.com The 1st Asian Congress on ADHD (2012년 11월 2일-3일)에서 포스터 발표하였음. ORIGINAL ARTICLE http://dx.doi.org/10.5765/jkacap.2014.25.2.89 J Korean Acad Child Adolesc Psychiatry 2014;25(2):89-94 online © ML Comm