_____________________________________________________________________________________________________ *Corresponding author: E-mail: nadendla2000@yahoo.co.in; Journal of Pharmaceutical Research International 33(5): 85-91, 2021; Article no.JPRI.66153 ISSN: 2456-9119 (Past name: British Journal of Pharmaceutical Research, Past ISSN: 2231-2919, NLM ID: 101631759) Physico-Chemical Characterization of Paliperidone Palmitate and Compatibility Studies with its Pharmaceutical Excipients Rama Rao Nadendla 1* , Prachet Pinnamaneni 1 , Siva Prasad Morla 1 and Patchala Abhinandana 1 1 Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur-522034, Andhra Pradesh, India. Authors’ contributions This work was carried out in collaboration among all authors. Author RRN designed the study. Author PP performed the statistical analysis, wrote the protocol and wrote the first draft of the manuscript. Author SPM managed the analyses of the study. Author PA managed the literature searches. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JPRI/2021/v33i531183 Editor(s): (1) Dr. Rafik Karaman, Al-Quds University, Palestine. Reviewers: (1) Yasin Hasan Balcioglu, Bakirkoy Prof. Mazhar Osman Training and Research Hospital for Psychiatry, Neurology and Neurosurgery, Turkey. (2) Gregory McIntire, USA. Complete Peer review History: http://www.sdiarticle4.com/review-history/66153 Received 20 December 2020 Accepted 24 February 2021 Published 01 March 2021 ABSTRACT Aim: The main aim of the present study was to characterize and perform the compatibility studies of paliperidone with its excipients. Study Design: Physico-chemical characterization and compatibility studies. Place and Duration of the Study: Chalapathi Drug Testing Laboratory, Chalapathi Institute of Pharmaceutical Sciences, Chalapathi Nagar, Lam, Guntur-522034 between December 2020 and January 2021. Methodology: Physico-chemical characterization and compatibility studies of paliperidone palmitate with its excipients like HPMC, lactose, magnesium stearate, talc, microcrystalline cellulose was done using the FTIR spectrophotometer, Scanning electron microscopy, X-ray diffraction, Differential scanning calorimeter. Results: Interaction of the paliperidone palmitate with its excipients were studied by this technique. Paliperidone palmitate showed the transition at 117.92 0 C with the specific heat of 101.9J/g. The IR Original Research Article