Outcomes and long-term survival of coronary artery surgery: The controversial role of opium as risk marker Mahdi Najaf, Leila Jahangiry, Seyedeh Hamideh Mortazavi, Arash Jalali, Abbasali Karimi, Ali Bozorgi Mahdi Najaf, Department of Anesthesiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran 1411713138, Iran Mahdi Najafi, Seyedeh Hamideh Mortazavi, Arash Jalali, Department of Research, Tehran Heart Center, Tehran University of Medical Sciences, Tehran 1411713138, Iran Leila Jahangiry, Department of Health Education and Promotion, School of Public Health, Tabriz University of Medical Sciences, Tabriz 5165665931, Iran Abbasali Karimi, Department of Cardiothoracic Surgery, Tehran Heart Center, Tehran University of Medical Sciences, Tehran 1411713138, Iran Ali Bozorgi, Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran 1411713138, Iran Author contributions: Najafi M designed the study; Najafi M, Jahangiry L, Karimi A, Bozorgi A performed the research; Mortazavi SH and Jalali A analysed the data; Najafi M and Mortazavi SH wrote the paper; Najaf M revised the manuscript for fnal submission. Institutional review board statement: The study was reviewed and approved by the Tehran Heart Center Institutional Review Board. Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment. Confict-of-interest statement: The authors declare no confict- of-interest. Data sharing statement: No additional data are available. Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/ licenses/by-nc/4.0/ Manuscript source: Invited manuscript Correspondence to: Mahdi Najaf, MD, Associate Professor, Department of Anesthesiology, Tehran Heart Center, Tehran University of Medical Sciences, North Kargar Street, Tehran 1411713138, Iran. najafk@sina.tums.ac.ir Telephone: +98-21-88029674 Fax: +98-21-88029731 Received: June 14, 2016 Peer-review started: June 17, 2016 First decision: July 27, 2016 Revised: August 16, 2016 Accepted: September 7, 2016 Article in press: September 8, 2016 Published online: November 26, 2016 Abstract AIM To study survival in isolated coronary artery bypass graft (CABG) patients and to evaluate the impact of preoperative chronic opium consumption on long-term outcome. METHODS Cohort of 566 isolated CABG patients as Tehran Heart Center cardiac output measurement was conducted. Daily evaluation until discharge as well as 4- and 12-mo and 6.5-year follow-up information for survival status were fulflled for all patients. Long-term 6.5-year overall and opium-stratified survival, adjusted survival curves based on opium consumption as well as possible predictors of all-cause mortality using multiple cox regression were determined by statistical analysis. ORIGINAL ARTICLE Submit a Manuscript: http://www.wjgnet.com/esps/ Help Desk: http://www.wjgnet.com/esps/helpdesk.aspx DOI: 10.4330/wjc.v8.i11.676 676 November 26, 2016|Volume 8|Issue 11| WJC|www.wjgnet.com World J Cardiol 2016 November 26; 8(11): 676-683 ISSN 1949-8462 (online) © 2016 Baishideng Publishing Group Inc. All rights reserved. World Journal of Cardiology WJC Prospective Study