International Journal of Trend in Scientific Research and Development (IJTSRD) Volume 4 Issue 1, December 2019 Available Online: www.ijtsrd.com e-ISSN: 2456 – 6470 @ IJTSRD | Unique Paper ID – IJTSRD29702 | Volume – 4 | Issue – 1 | November-December 2019 Page 847 Formulation Development and Evaluation of Oral Fast Dissolving Films of Metaclopromide HCL Zeenath Ruhy Assistant Professor, Department of Pharmaceutics, Mother Teresa College of Pharmacy, N.F.C Nagar, Ghatkesar, Medchel, Telangana, India ABSTRACT Metaclopromide-HCl is an Anti-emetic used to treat nausea, vomiting and to increase gastric motility. The present work aimed at preparing oral fast dissolving films of Metaclopromide-HCl with the purpose of developing a dosage form for a very quick onset of action, which is very convenient for administration, without the problem of swallowing and using water. Oral fast dissolving films of Metaclopromide-HCl were prepared using HPMC (E5, E15) polymers as film forming agents and polyethylene glycol-400 as plasticizer by solvent casting method. FTIR showed that there is no interaction between drug and excipients. Dissolution of prepared fast dissolving oral films of Metaclopromide-HCl was performed using USP type II apparatus in pH 6.8 phosphate buffer medium at 50 rpm with temperature being maintained at 37 0.5º C. The films prepared were evaluated for various parameters like thickness, drug content uniformity, weight variation, disintegration time, folding endurance and in vitro drug release and were showed satisfactory results. In conclusion, development of oral fast dissolving oral films using HPMC polymer gives rapid drug delivery and rapid onset of action. KEYWORDS: Oral fast dissolving films, Metaclopromide, HPMC How to cite this paper: Zeenath Ruhy "Formulation Development and Evaluation of Oral Fast Dissolving Films of Metaclopromide HCL" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-1, December 2019, pp.847-852, URL: www.ijtsrd.com/papers/ijtsrd29702.pdf Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by /4.0) INRODUCTION One of the most crucial routes of administrating a drug with high credit to obtain a systemic effect is the oral administration for its simplicity, comfortability by producing no pain compared with the systemic administration and other remarkable benefits over the other routes[1]. However, it also comes with disadvantages in case of certain dosage forms as capsules and tablets, as problems of swallowing especially for children and infants and for elders leading to incompliance and disadherence to the treatment [2]. This was proved by evidence that approximately 35% of the population showed dysphasia and troubles with swallowing as an example, people with sea/ motion sickness, hiccups, gagging and obstruction of the esophagus pathway will be force to search for other alternatives which favor the systemic drug delivery such as fast dissolving medication [3]. Oral fast-dissolving film is new drug delivery system developed on the basis of the Transdermal patch [4]. It consists of a very thin oral strip, which is simply placed on the tongue or oral mucosal tissue, instantly wet by saliva; the film rapidly hydrates and adheres onto site for rapid disintegration and release [5].The objective of the present study was to develop Oral fast dissolving films (OFDFs) of Metaclopromide- HCl as Anti-emetic and to provide a convenient means of administration to those patients suffering from nausea and vomiting and to increase gastrointestinal motility. MATERIALS AND METHODS Metaclopromide- HCl was obtained as a gift sample from Aurobindo Ltd., HPMC E5, E15 was used as polymers, PEG 400, Ascorbic acid, and Aspartame is obtained from SD Fine Chemicals. Formulation of Metaclopromide-HCl oral fast dissolving films The procedure of making of Metaclopromide HCl ODF All materials were weighed. Some polymers are dissolved in distilled water. Then left in for 10 minutes to swell. Drug is dissolved in distilled water, then added aspartame and ascorbic acid. The solution was stirred until all the material is completely dissolved. Drug substance solution is added to the base polymer. PEG 400 was added to the polymer solution while stirring. The solution was left in at room temperature to remove air bubbles. After the air bubbles disappear, the solution was poured into a mold 9 cm x 10 cm until blended. Film dried at 40°C in the drying cabinet for 24 hours. After drying, the film removed from the mold carefully and cut the size of 2 cm x 3 cm [6]. The components of the formulation were shown in Table 1. IJTSRD29702