February 2022 · Volume 11 · Issue 2 Page 315 International Journal of Reproduction, Contraception, Obstetrics and Gynecology Chukwu JA et al. Int J Reprod Contracept Obstet Gynecol. 2022 Feb;11(2):315-322 www.ijrcog.org pISSN 2320-1770 | eISSN 2320-1789 Original Research Article A decade study of the incidence and clinical analysis of ectopic pregnancy at a tertiary hospital in Eastern Nigeria Jemima A. Chukwu 1 *, Ambrose E. Agulanna 1 , Izuchukwu A. Okafor 1,2 , Agnes A. Nwakanma 3 , Blessing C. O. Osuji 4 INTRODUCTION EP is a pregnancy in which a fertilized egg gets implanted in a site other than the endometrium of a woman’s uterus. It is a life-threatening gynecological emergency, one of the leading causes of pregnancy-related death in the first trimester and a major concern to female fertility. 1,2 Following the last three decades, the incidence of EP has increased nearly to the level of an epidemic disease with variations from country to country, region to region and even within the same geographical region. 3,4 Globally, the incidence of EP ranges from 1.0%-2.0%. 5 A review by Liskin reported that the highest incidence of EP from the 1960s to the mid-1980s was observed in African countries DOI: https://dx.doi.org/10.18203/2320-1770.ijrcog20220154 1 Department of Anatomy, Nnamdi Azikiwe University, Anambra State, Nigeria 2 Department of Obstetrics and Gynecology, Pan African University of Life and Earth Science Institute (Including Health and Agriculture), University of Ibadan, Nigeria 3 Department of Anatomy, Chukwuemeka Odumegwu Ojukwu University, Anambra State, Nigeria 4 Department of Medical Services, Nigerian Ports Authority, Delta State, Nigeria Received: 22 December 2021 Accepted: 12 January 2022 *Correspondence: Jemima A. Chukwu, E-mail: ja.chukwu@stu.unizik.edu.ng Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Background: Ectopic pregnancy (EP), a condition where a fertilized egg grows outside a woman’s uterus, is a fertility- and life-threatening gynecological condition. This study aimed at determining the incidence of EP, clinical presentation, gestational age at presentation, risk factors and treatment modalities. Methods: This study was conducted at St. Charles Borromeo specialist hospital, Onitsha, Nigeria (January 2009 to December 2018). Information were obtained from the hospital’s medical records as retrieved from va rious wards. Data were analyzed using IBM SPSS, version 23, then presented as percentage in tables and figure. Results: Out of 13,402 pregnancies recorded in this study, 119 were EPs giving an incidence of 0.89%. 105 case notes were included in this study since they met the inclusion criteria. Majority of the women belonged to the age group of 26-30 years. Patients with EP presented more between 7-8 weeks of gestational age (40%), though 7.6% were unsure of their last menstrual period. 80 EP cases (76.2%) were ruptured while 25 (23.8%) were unruptured. The ectopic gestation occurred most at the ampulla (51.4%) and more at the right side (66.6%) than the left (33.4%). Pelvic inflammatory disease (30.4%) followed by prior abortion (20.0%) were major predisposing risk factors. The most common clinical presentations were abdominal pain (92.38%), amenorrhea (57.14%) and vaginal bleeding (51.42%). 85.7% had salpingectomy, 9.5% were medically managed. Conclusions: EP remains a major gynecological emergency. Diagnosis before rupture could offer an opportunity for a successful medical management, thereby; minimizing morbidity and mortality. Keywords: Ectopic pregnancy, Amenorrhea, Salpingectomy, Gestational age