ISSN: 0975-8585 March–April 2016 RJPBCS 7(2) Page No. 303 Research Journal of Pharmaceutical, Biological and Chemical Sciences Evaluation of Candida albicans adherence to different denture base materials Mohamed K Mousa, Amani R Moussa*, and Hisham S ElGabry Prosthodontics Dept, National Research Centre, Egypt. ABSTRACT Although, polymethyl methacrylate (PMMA) resin has been the most commonly used material for denture bases, PMMA suffers from major drawbacks. To overcome PMMA resin problems, a new injection modeling thermoplastic resin has been developed. The aim of this study was to compare the adherence of Candida Albicans to heat cured resin and thermoplastic resin cured by injection modeling technique. Fourteen completely edentulous patients were selected. New complete dentures were fabricated where seven patients received conventional heat cured dentures (Group I) and Group (II), received thermoplastic dentures. Swabbing technique and germ test tube were used for C. Albicans isolation and identification following two and four months of denture insertion. Student’s t-test was used to compare between the two groups. Heat cured resin showed statistically significantly higher mean colony forming unit (CFU) counts than thermoplastic resin (p<0.05). Both groups revealed a significant increase in CFU counts by time (p<0.05). Despite of the significant increase in Candida albicans CFU of heat cured resin compared to thermoplastic resin, a higher % of Candida albicans CFU to thermoplastic resin was clear (p<0.05). Hence it could be concluded that Candida albicans adherence to dentures is unavoidable, therefore, strict oral hygiene measures is required Keywords: Candida Albicans, heat-cured resin, injection molded resin. *Corresponding author