Available online at www.derpharmachemica.com Scholars Research Library Der Pharma Chemica, 2011, 3 (6):213-223 (http://derpharmachemica.com/archive.html) 213 www.scholarsresearchlibrary.com ISSN 0975-413X CODEN (USA): PCHHAX Synthesis of Novel 4-Thiazolidinone Derivatives Incorporated with Benzothiazole and its Antimicrobial Activity Sambhaji. P. Vartale*, Digambar. B. Kadam , and Nilesh. K. Halikar P.G. Research Centre, Department of Chemistry, Yeshwant Mahavidyalaya, Nanded(MS) India ______________________________________________________________________________ ABSTRACT A series of novel tetrazoloquinoline schiff’s bases 3a-g,4a-g,5a-g,6a-g,7a-g were prepared from 6/7/8-trisubstituted quinoline carbaldehyde . All tetrazolo quinoline Schiff bases were refluxed with thioacetic acid in presence of anhydrous zinc chloride and solvent N,N-dimethyl formamide to afforded novel series of 4-thiazolidinone 8a-g,9a-g,10a-g,11a-g,12a-g.All synthesized 4- thiazolidinone were screened for their antimicrobial activity. Keywords: Schiff bases, 4-Thiazolidinones, tetrazoloquinoline, antimicrobial activity, acetic acid. ______________________________________________________________________________ INTRODUCTION Quinoline and its derivative is an interesting class of heterocyclic compounds with a wide range of applications as a drug. Most of the Quinoline derivatives act as analgesics [1], antiamoebic [2- 5], tryphocidal [6], antiseptic [7] and antiserotonin [8]. In addition to these, derivatives also exhibit good antimalerial [9-10] antitubercular [11], antibacterial [12], antihistaminic [13], antineurodegerative [14], anticonvulsant [15], antitumor [16], anticancers [17-18] and antiallergics [19] activities. And also moreover fusion of tetrazole, which is considered as planar acidic heterocyclic analogue of carboxylic function [20-21] have ability to increase potency [22-23] and improve bioavailability[24] Similarly schiff’s bases have been reported to possess antimicrobial [25-26 ]apart from other biological activities. These observations led to the conception that Schiff’s bases of synthesis of schiff’s bases of 8-methyl- tetrazolo[1,5-a] quinoline as potential anti- inflammatory and antimicrobial agents [27].After successful literature survey it stimulate us to synthesize 2-(7/8/9-tri substituted tetrazolo[1,5-a]quinolin-4-yl)-3- (substituted benzothiazol-2-yl) thiazolidin-4-ones and purity of the compound was checked by TLC and structure of the compound was deduced on the basis of their IR, 1 H NMR and mass spectroscopy. The synthesis of compounds 8a-g,9a-g,10a-g,11a-g,12a-g. is mentioned in scheme-2 and their antimicrobial data in Table1.