Submit Manuscript | http://medcraveonline.com Introduction The common human corona viruses 229 E (alpha corona virus), NL63 (alpha corona virus), OC43 (beta corona virus) and HKU1 (beta corona virus) result in common cold. It is now clear that there are 3 human corona viruses that lead to a more severe acute illness; MERS-CoV that lead to Middle East respiratory syndrome (MERS), SARS-CoV that causes severe acute respiratory syndrome (SARS) and SARS-CoV-2 the reason for COVID-19. There are inadequate case series that document the efect of covid-19 during gestation. In women infected by SARS or MERS, the mortality is higher in those infected during gestation in comparison to non-pregnant women. 1 Discussion There are no data on corona infection during frst trimester of gestation. In a previous study, miscarriage occurred to four of seven cases. 2 A case was reported with sore throat and fever with positive covid-19 infection at 34 weeks with deterioration of her condition and ICU admission and needed ECMO, her baby was still birth and delivered by CS. 3 Zhang et al. 4 documented a series of 5 pregnant ladies with positive SARS, 2 of them in the second trimester, 3 in third trimester, fetal death occurred in one fetus in a twin pregnancy while the other survived till the end of pregnancy. 4 2 pregnancy losses were documented in women infected with MERS. One fetal loss happened at 20 weeks. 5 Chen et al. 6 made a study showed that among 32 women that had COVID-19, 15 pregnant women had a preterm delivery. 6 In a research made by Zhu et al. 7 7 pregnant ladies who delivered by CS and 2 by vaginal delivery; 5 females out of 9 women delivered preterm. 7 Liu et al. documented that among 13women, 7 had preterm labour by CS; while the cause for preterm labour was not mentioned. 3 In a previous study regarding MERS, 3 of 11 pregnant ladies with MERS were delivered preterm. 8,9 In a previous study on women with COVID–19, they delivered within 2 weeks of start of symptoms, the fetal growth isnot possible to be infected in this small time and there were no available information regarding placental pathology till now. 3,6,7,10 In pregnant women with SARS, when delivery was made after less than one week of symptoms, placental pathology showed deposition of fbrin but with no fetal growth restriction while when delivery was made after fve to seven weeks, there was growth restriction avascular villi and bleeding behind placenta and abruption. 11 Samples from umbilical cord blood amniotic fuid, neonatal throat swab and breast milk showed no proof of CPVID-19 in 6 pregnancies delivered by CS. 6 In a study made by Liu et al. 3 revealed that samples from 10 pregnancies showed delivered by CS showed no vertical transmission. 3 Moreover, there were no reported cases of vertical transmission for SARS or MERS during gestation either when pregnancy ended by vaginal route or by Cesarean section. Regarding neonatal outcome in COVID-19 infection, in a study made by Chen et al. 6 no neonatal problems were reported. 6 While Zhu et al. 7 revealed that in babies delivered at gestational age (from 31 weeks); 6 out of 10 neonates were admitted to the ICU for breathing maintenance, two had disseminated intravascular coagulation (DIC) and one developed multi organ failure 4. 7 From the presently available documentations, an increase in the risk of miscarriage in women afected by COVID-19 cannot be excluded at this stage. 1 Delayed cord clamping is not advised by ISUOG nor by China Consensus guidance to reduce risk of vertical transmission. 12 Recommendations from China reported that breast feeding should not be ofered to infants of suspected or confrmed COVID -19 while Centre for Disease Control and prevention guidance is less obvious but they advise a cautionary recommendations. 13 Obstet Gynecol Int J. 2021;12(2):64‒67. 64 ©2021 Alalfy et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and build upon your work non-commercially. Covid -19 during pregnancy, labour and postnatal: A review article Volume 12 Issue 2 - 2021 Mahmoud Alalfy, 1 Ahmed Elgazzar, 2 Osama Azmy, 1 Ahmed Hassan 3 1 Reproductive health and family planning department, National Research Centre, Egypt 2 Obstetrics and Gynecology department, Cairo University, Egypt and Consultant OB/Gyn, Aljazeerah Hospital, Egypt 3 Head of Obstetrics and Gynecology Department, Helwan University, Egypt Correspondence: Mahmoud Alalfy, PhD, Reproductive health and family planning department, National Research Centre, Dokki, P.O 12622, Egypt. Affliation ID 60014618 and Consultant OB/Gyn, Aljazeerah Hospital, Egypt, Tel +201002611058, Email Received: February 18, 2021 | Published: March 08, 2021 Abstract Objectives: The aim was to make a review on COVID-19 during pregnancy to help in establishment of management plans for pregnant women with corona virus and during labour and postnatal care of the neonates. Methods: Searches were made in PubMed to detect, recent studies regarding COVID–19 during pregnancy. Data were taken out from relevant manuscripts. Conclusion: In comparison to MERS and SARS, COVID-19 seems less lethal, as regard to the inadequate number of cases documented till now. A low-molecular-weight heparin should be given for pregnant women with COVID-19 to reduce the risk of thrombosis. Keywords: pregnant, women, COVID-19–virus Obstetrics & Gynecology International Journal Review Article Open Access