330 TOXICITY EVALUATION STUDY OF CHLORHEXIDINE USED IN DENTAL TREATMENT OVIDIU MOTOC 1 , ANGELA CODRUŢA PODARIU 2 , DANIELA JUMANCA 2 , ANCA PORUMB 1 , DAN ONISEI 2 , FLORINA ANDRICA 3 , RAMONA AMINA POPOVICI 2 1 University from Oradea 2 Faculty of Dentistry, University of Medicine and Pharmacy”Victor Babes”Timișoara 3 Faculty of Pharmacy, University of Medicine and Pharmacy”Victor Babes”Timișoara ABSTRACT The aim of this study is the biological evaluation of chlorhexidine used in periodontal disease and disinfection of root canals. This compound is a broad spectrum antibacterial agent and is currently used as a local antiseptic. At low concentrations it has bacteriostatic effect and at high concentrations it has bactericidal effect. At low concentrations cell death occurred through apoptosis, and at higher concentrations, chlorhexidine induced necrosis. Key words: chlorhexidine, topical application, cytotoxic effect; non-invasive skin measurements Correspondence to: Ramona Amina Popovici Address: University of Medicine and Pharmacy”Victor Babes”Timișoara, Department of Preventive Dentistry Phone: +4 0762006828 E-mail address: ramona.popovici@umft.ro