337 Original Article Correlation between working memory and quality of life in multiple sclerosis patients Chehreh-Negar N 1 , Shams F 1* , Zarshenas S 2 , Nikseresht AR 3 1- Department of Occupational Therapy, Faculty of Rehabilitation, Shiraz University of Medical Sciences, Shiraz, I. R. Iran. 2- Department of Occupational Therapy, Faculty of Rehabilitation, Isfahan University of Medical Sciences, Isfahan, I. R. Iran. 3- Department of Neurology, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, I. R. Iran. Received September 22, 2011; Accepted December 22, 2012 Abstract: Background: Working memory impairment is one of the most important cognitive deficits in multiple sclerosis (MS) patients that affect the quality of life even in the early stages of the disease. The purpose of this study was to evaluate the correlation between the working memory and the quality of life in MS patients. Materials and Methods: This case-control study was performed on 35 (case) and 28 healthy (control) participants. Working memory and quality of life were assessed using Wechsler adult intelligence scale and the MS quality of life 54 (MSQOL-54) inventory, respectively. Results: Results showed a significant difference between the two groups in the means of working memory in both auditory (P<0.001) and visual span (P<0.0001) as well as physical quality of life (P<0.04). Moreover, logistic regression analysis showed that MS disease had an impact on both physical (OR= 0.679 and CI= 0.889-0.519) and mental (OR= 0.929 and CI= 0.857-0.998) components of the quality of life. Conclusion: Findings of the study indicate that cognition is an effective factor to engage in activities of daily living. Moreover, the relation between the working memory impairment and the quality of life in MS patients highlights the importance of the early recognition of cognitive deficit. Keywords: Multiple sclerosis, Working memory, Quality of life, Wechsler adult intelligence scale * Corresponding Author. Email: sh_00_f@yahoo.com Tel: 0098 917 713 1859 Fax: 0098 711 627 2495 Conflict of Interests: No Feyz, Journal of Kashan University of Medical Sciences September, 2012; Vol. 16, No 4, Pages 337-345 Please cite this article as: Chehreh-Negar N, Shams F, Zarshenas S, Nikseresht AR. Correlation between working memory and quality of life in multiple sclerosis patients. Feyz 2012; 16(4): 337-45. Downloaded from feyz.kaums.ac.ir at 23:10 +0330 on Saturday November 27th 2021