Early Detection of Coronary Artery Diseases Using Endocrine Markers Felician Jonathan More 1 , Zenon Chaczko 1,2 , and Julita Kulbacka 2,3(B ) 1 School of Electrical and Data Engineering, University of Technology Sydney, Ultimo, Australia felician.j.more@student.uts.edu.au, zenon.chaczko@uts.edu.au 2 DIVE IN AI, Wroclaw, Poland 3 Faculty of Pharmacy, Department of Molecular and Cellular Biology, Wroclaw Medical University, Wroclaw, Poland julita.kulbacka@umed.wroc.pl Abstract. Cardiovascular diseases including coronary artery disease is the leading cause of death in the well developed and developing countries of the 21st century and has a higher rate of mortality and morbidity. Dysfunction of the pituitary, thyroid, and parathyroid glands caused cardio/cardiovascular diseases including changes in blood pres- sure, contractility of myocardium - systolic and diastolic myocardial func- tions, endothelial and dyslipidemia. Dysfunction of thyroid, parathyroid and adrenocorticotropic hormones caused imbalance of endocrine sys- tem such as hyper and hypo function, effects on pathophysiology of the cardiovascular system. Keywords: Cardiovascular disease · Thyroid dysfunction · Endocrine markers 1 Background Cardio/cardiovascular diseases were the prime cause of death in the world in the 21st century and had a higher rate of morbidity and mortality. Statistical analysis reveal that 12–14% of men and 10–12% of women between the age of 65 and 84 years have been treated for angina. In the United States of America, one in three individuals around 92.1 million have cardiovascular diseases including 10 million adults with angina pectoris, and also it is stated that there were 836,546 deaths with one in three deaths in USA; of which 46% were males and 47.7% of women in non-Hispanic black adults had died in the USA in some form of cardiovascular diseases, and 2,300 people died each day. In USA 43.8% of deaths were the cause of coronary artery diseases and accounts for one in 7 deaths. In Australia, CAD is the main cause of cardiovascular disease. Australian Bureau of Statistics of National Health Survey in 2014–2015 report shows, that 645,000 people aged 18 and over had CAD and affecting one in six individuals aged 75 and over. In 2015 hospital based on data revealed that 61,600 individuals c  Springer Nature Switzerland AG 2020 N. T. Nguyen et al. (Eds.): ACIIDS 2020, LNAI 12034, pp. 593–601, 2020. https://doi.org/10.1007/978-3-030-42058-1_50