Professional Med J 2015;22(1): 076-080. www.theprofessional.com C-REACTIVE PROTEIN (CRP) 76 The Professional Medical Journal www.theprofesional.com C-REACTIVE PROTEIN (CRP); IN PATIENTS WITH METABOLIC SYNDROME Dr. Shuaib Ansari 1 , Dr. Irfan Murtaza Shahwani 2 , Dr. Zeeshan Ali 3 , Dr. Syed Zulfquar Ali Shah 4 , Dr. Faisal Shahab 5 ORIGINAL PROF-2597 ABSTRACT… Objective: To determine the frequency of raised C-reactive protein (CRP) in patients with metabolic syndrome. Patients and methods: This cross sectional descriptive study of six months study was conducted at Liaquat University Hospital Hyderabad. All the patients of 20 to 60 years of age, of either gender presented with symptoms of metabolic syndrome for more than 01 year duration were admitted and evaluated for C-reactive protein. The data was analyzed in SPSS 16 and the frequency and percentage was calculated. Results: Total one hundred patients (59 females and 41 males) with metabolic syndrome were evaluated for C-reactive protein. The mean waist circumference for males and female patients with raised CRP was 48.93±2.33 and 48.42±3.41 while the mean ±SD of serum triglycerides level for male and female with raised CRP was 192.41±3.21 and 196.31±3.43 respectively. The mean ±SD of serum HDL-C level for male and female with raised CRP was 28.32±1.22 and 25.31±1.42. The mean ±SD of systolic and diastolic pressure for males and female patients with raised CRP was 150±3.42 and 100.51±4.42. The mean ±SD of serum fasting blood sugar for male and female patients with raised CRP was 131.52±3.33 and 143.42±7.42 respectively. The mean ±SD of CRP for male and female patients with raised CRP was 4.42±1.21 and 5.8±2.52. In relation to gender distribution, the majority of subjects from 40-49 years of age group with female predominance (p = 0.01) while the CRP was raised in 67% patients in relation to age (p=0.05) and gender (p=0.04) respectively. Out of 67 subjects with raised CRP 44 were females and 23 were males. Conclusions: The CRP was raised in patients with metabolic syndrome. Key words: Metabolic syndrome, Triglycerides, High Density Lipoprotein, Hypertriglyceridemia, Lipoproteins, Syndrome X, Obesity and Hypertension 1. FCPS Associate Professor Department of Medicine Liaquat University of Medical and Health Sciences (LUMHS) Jamshoro 2. MD Consultant Physician Department of Medicine, Medical – III, ward 06 Liaquat University Hospital Hyderabad / Jamshoro 3. FCPS Senior Registrar Department of Medicine, unit-III, ward 07 Jinnah Postgraduate Medical Center Karachi 4. Postgraduate Department of Medicine Liaquat University of Medical and Health Sciences (LUMHS) Jamshoro 5. MBBS Registrar Department of Medicine, Medical unit-III, ward 06 Liaquat University Hospital Hyderabad / Jamshoro Correspondence Address: Dr. Syed Zulfquar Ali Shah House No: 279, Doctor’s Colony Hirabad, Hyderabad, Sindh, Pakistan zulfkar229@hotmail.com Article received on: 21/07/2014 Accepted for publication: 18/09/2014 Received after proof reading: 17/01/2015 Article Citation: Ansari S, Shahwani IM, Ali Z, Shah SZA, Shahab F. C-reactive protein (CRP); in patients with metabolic syndrome. Professional Med J 2015;22(1):076-080. INTRODUCTION The metabolic syndrome (MS) associated with ischemic heart disease, fatty liver and several malignancies 1,2 . The syndrome includes raised triglycerides level and blood pressure, reduced high-density lipoprotein cholesterol (HDL-C), hyperglycemia and increase waist circumference 3 . The insulin resistance frequently occurs in metabolic syndrome which leads to diabetes mellitus, NAFLD, hypertension, cholilithiasis, polycystic ovarian syndrome, obesity and sleep apnoea 4,5 . The prevalence of metabolic syndrome in Pakistan reported by Basit A, et al was 46%, 6 while the proportion for each component of metabolic syndrome formerly reported was increase waist circumference 28%, hypertension 23.8%, hyperglycemia 4.7%, reduced HDL-C 87.6% and hypertriglyceridemia 12.5% 5 . C-reactive protein (CRP) is an acute phase protein and infammatory marker synthesized by liver 7 . The cytokines like IL1, IL6 and TNF stimulate the production of CRP in response to infection and infammation 8 . Metabolic syndrome also considered a proinfammatory state and by evaluating the CRP reduction in the prediction for cardiovascular disease and diabetes can be possible 9,10 . Former studies considered CRP as a component of metabolic syndrome 11-15 . The prevalence of raised C-reactive protein in patients with MS reported by Ford ES, et al was 38% 16 . The study was evaluate the disturbance in CRP in patients with MS, as the infammatory property of CRP is the main route to acquire cardiovascular and cerberovascular accident in patients with metabolic syndrome, so early identifcation and