_____________________________________________________________________________________________________ *Corresponding author: Email: safa30sharaffadin@gmail.com; International Journal of TROPICAL DISEASE & Health 42(12): 30-39, 2021; Article no.IJTDH.73278 ISSN: 2278–1005, NLM ID: 101632866 Histopathological Aspects of Cutaneous Leishmaniasis due to Leishmania-Major in Libya Safa Sharfuldeen 1* , Badereddin Annajar 2 , Hamida Al-Dwibe 1 , Said El-Zubi 1 and Ahmeda Benjama 3 1 Department of Dermatology, Tripoli Central Hospital, Tripoli, Libya. 2 Department of Parasitic and Vector Borne Diseases, Faculty of Medical Technology, University of Tripoli, Libya. 3 Department of Histology and Genetic Science, Faculty of Medicine, University of Tripoli, Tripoli, Libya. Authors’ contributions This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Article Information DOI: 10.9734/IJTDH/2021/v42i1230501 Editor(s): (1) Dr. Zhiheng Zhou, Harvard medical school, USA and Guangzhou university, China. Reviewers: (1) Fatemeh Kazemi-Lomedasht, Pasteur Institute of Iran, Iran. (2) Bhavanam Sudhakara Reddy, Sri Venkateswara Veterinary University, India. Complete Peer review History: https://www.sdiarticle4.com/review-history/73278 Received 21 June 2021 Accepted 01 September 2021 Published 10 September 2021 ABSTRACT Aims: To describes the histopathological characteristics of skin lesions from patients with cutaneous leishmaniasis caused by Leishmania major in northwestern Libya and correlate with clinical presentation. Study Design: case series study. Place and Duration of Study: This study was carried on patients referred by the region's healthcare institutions and those presented at the Tripoli Central Hospital or the Libyan National Centre for Disease Control between July 2017 to January 2018. Methodology: The study included 38 patients, aged between 1-73 years, of both sexes, and came from 18 endemic areas in North-Western of Libya. The inclusion criteria were clinical symptoms and microscopic visualization of the parasite on a Giemsa-stained skin smear, in addition, clinical by the slit and smear technique, polymerase chain reaction for L. major. In addition, statistical analysis was conducted for the Histopathological examination. Original Research Article