T HE INTERNATIONAL ARABIC JOURNAL OF ANTIMICROBIAL AGENTS ISSN: 2174-9094 1 2020 Vol. 10 No. 3:3 doi: 10.3823/850 © Under License of Creative Commons Attribution 3.0 License This article is available at: www.iajaa.org iMedPub Journals http://journals.imed.pub Abstract Introduction: In the United States, the total number of confirmed reported cases of Covid-19 had reached 6.45 million with a total death of 193, 246 as of Sept 6, 2020. Significant efforts have been invested to flatten the curve and control new cases appearing in the socie- ties. Meanwhile, the governments has imposed a lockdown with the objective of controlling the transmission of the virus. The re-opening of societies is challenging and might involve threats, many of them remain unseen. Methods: We present here the validation of a Lateral Flow Immuno- chromatographic Assay in comparison with RT-PCR and describe a dynamic scenario to un-locking and re-opening societies using an evidence-based design, suggested by an algorithm of screening using RT-PCR and antibodies in a large population. Results and Conclusion: In the absence of highly reliable vaccine and/ or treatment for Covid-19, the decision to go back to work or stay at home remains controversial and risky. Controversial because our limited knowledge of the virus and risky in view of the uncertainty of acquired immunity. Attempts based on multi-analytical approaches, such as the algorithm presented here, are required for a better ma- nagement and a more flexible fine tuning of re-opening societies. Evidence-based progressive passage to reopening American societies post COVID-19 Ziad Daoud 1,2 , Jesse McLeod 1,2 , Offiang F. Ikpatt 1,2 , Magdalena Perez 1,2 , Marcus Atkins 2 , Tracy Speier 2 , David Stockman 1,2 1 Department of Clinical Microbiology and Infection Prevention, Michigan Health Clinic, 4707 McLeod Dr., Saginaw, MI 48604, USA. 2 Public Health Institute of Science, Epidemiology, and Research, 2200 Pennsylvania Ave, NW 4 th Floor East. Washington DC 20037, USA. Contact information: Dr. David Stockman.  DStockman@chs-mi.com Keywords Covid-19; Immuno-chromatographic Assay; RT-PCR; USA Population. Introduction As of September 6, 2020, the virus SARS-Cov2 had resulted in more than 27,282,417 infections and 887,277 deaths worldwide. The disease caused by this virus, COVID-19 has now been reported on every continent. In the United States, the total number of confirmed reported cases of Covid-19 Received 11-08-2020; Accepted 14-09-2020