TITLE PAGE Recurrent SPECC1L-NTRK fusions in paediatric sarcoma and brain tumours Dong-Anh Khuong-Quang 1,2,3 , Lauren M. Brown 1,3,4 , Marie Wong 1,10 , Chelsea Mayoh 1 , Alexandra Sexton-Oates 3 , Amit Kumar 1,5 , Mark Pinese 1 , Sumanth Nagabushan 6 , Loretta Lau 1,6 Louise E. Ludlow 3 , Andrew J. Gifford 1,7 , Michael Rodriguez 7 , Jayesh Desai 5,8 , Stephen B. Fox 8,9 , Michelle Haber 1 , David S. Ziegler 1,6 , Jordan R. Hansford 2,3,4 , Glenn M. Marshall 1,6 , Mark J. Cowley 1,10 and Paul G. Ekert 1,3,5,10 . 1. Children’s Cancer Institute, University of New South Wales, Randwick, 2031, Australia 2. Children’s Cancer Centre, Royal Children’s Hospital, Parkville, 3052, Australia 3. Murdoch Children’s Research Institute, Royal Children’s Hospital, Parkville, 3052, Australia 4. Department of Paediatrics, University of Melbourne, Parkville, 3052, Australia 5. Peter MacCallum Cancer Centre, Melbourne, 3000, Australia 6. Kids Cancer Centre, Sydney Children’s Hospital, Randwick, 2031, Australia 7. Department of Anatomical Pathology, Prince of Wales Hospital, Randwick, 2031, Australia 8. Sir Peter MacCallum Department of Oncology, University of Melbourne, Australia 9. Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, Australia 10. School of Women's and Children's Health, UNSW Medicine, UNSW Sydney, Randwick, 2031, Australia Corresponding author: Associate Professor Paul G. Ekert, Group Leader, Translational Tumour Biology, Children’s Cancer Institute, Randwick, NSW, Australia Email: PEkert@ccia.org.au Short running title: Recurrent SPECC1L-NTRK fusions Target journal: Molecular Case Studies Article type: Research Article Cold Spring Harbor Laboratory Press on February 23, 2022 - Published by molecularcasestudies.cshlp.org Downloaded from