J. Mountain Res. ISSN: 0974-3030
Vol. 13, (2018) 39-43
©SHARAD
A Short Synthesis of
Cedrus deodara by H
Tukaram Sukhadev Thopate
1
*
1
Department of Chemistry and Researc
414302, India
Corresponding Author Email: thopatenc
Received: 14.11.2018; Revised: 25.11.2
©Society for Himalayan Action Resear
Abstract: A short synthesis of ar- hima
p-iodotoluene with ethyl sorbate would
and Raney-nickel alloy gives the satur
ester with methyl magnesium iodide fo
would furnish a sesquiterpene, ar-himac
Keywords: Heck reaction • p-iodotolu
Introduction
A large number of natur
sesquiterpenes possesses a w
applications in drugs, pharmace
paints, perfumery, agriculture an
(Chavan et.al., 2012). Himachalene
and biologically important clas
occurring sesquiterpene hydr
synthetically challenging benzo(7
system (Silva, 2008; Srikrishn
Himachalene is found as essential o
several cedar woods, which include
Loud, Cedrus atlantica and Cedrus
Himalayan and Morroccon fore
1952). The different components
of Cedrus deodara shows insecticid
activity and therefore used in p
(Chaudhary et. al., 2011). Himac
isolated as pheromonial componen
Aphthona flava and Phyllotreta c
39 http://j
Sesquiterpene Ar- Himachale
Heck reaction
ch Center, New Arts, Commerce and Science College, Par
cl@rediffmail.com
2018 Accepted:10.12.2018
rch and Development
achalene was carried out by palladium catalyzed Heck re
d yield the conjugated ester. Further hydrogenation of con
rated ester in two steps and in high overall yield. Grigna
ollowed by Polyphosphoricacid cyclodehydration of the r
chalene.
uene • PPA • Sesquiterpene • ar- himachalene
rally occurring
wide range of
euticals, rubber,
nd many others
e is a structurally
ss of naturally
rocarbons the
7]annulene ring
na et.al, 2004).
oil extracted from
e Cedrus deodara
s libani found in
ests (Rao et.al.,
and essential oil
dal and larvicidal
pest management
chalene was also
nt of flea beetles;
cruciferae, which
are typically produced by onl
both sexes (Bartlet et. al., 2001
The structure of ar-himachalen
basis of spectral evidences
synthesis has carried out by
routes first time based on spect
et.al., 1968; Pandey et. al.
synthetic approach of ar- hima
by the use of tricyclic sesquiter
a complex starting compound
Recently, an enantioselectiv
himachalene was reported by
approach (Mori, 2005). The
acyl derivatives of its shows
(Chaudhary et. al., 2014).
In recent years, the palladium
haloarenes and haloalkenes wit
carbon-carbon bonds, Heck rea
interest in the synthesis of natu
et. al., 2011). Heck reaction ha
jmr.sharadpauri.org
ene from
rner, Ahmednagar (MS)
eaction. Heck reaction of
njugated ester by NaOH
ard reaction of saturated
resultant tertiary alcohol
ly one sex but attract
1).
ne has proved on the
and its laboratory
y two different long
tral evidences (Joseph
., 1968). The third
achalene was reported
rpene viz. longifolene,
(Mehta et. al., 1974).
ve synthesis of ar-
y chirality induction
synthesized aryl and
antimicrobial activity
catalyzed coupling of
th olefins to form new
action have gained our
ural products (Hossini
s opened the door to a