International Journal of Collaborative Research on Internal Medicine & Public Health Vol 12 No. 5 (2020) 1037 Prevalence of Hepatitis B and C Viruses among Blood Donors at National Blood Bank Addis Ababa, Ethiopia Samuel Abebe Mekuria 1 , Tesfaye Girma Legesse 2* , Alemayehu Worku Yalew 3 1 Department of Internal Medicine, Saint Paul’s Hospital Millennium Medical College, Addis Ababa University, Addis Ababa, Ethiopia 2 Department of Nutrition, Saint Paul’s Hospital Millennium Medical College, Addis Ababa University, Addis Ababa, Ethiopia 3 Department of Preventive Medicine, School of Public Health, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia * Corresponding author: Dr. Tesfaye Girma Legesse, Department of Nutrition, Saint Paul’s Hospital Millennium Medical College, Addis Ababa University, Addis Ababa, Ethiopia, Tel: 251913227913; E-mail: girmanet12@ gmail.com Abstract Background: Despite the implementation of efective vaccination programs, hepatitis B and C remains an important cause of morbidity and mortality worldwide. Undersanding the epidemiology of the diseases is essential in developing programs to prevent and treat this global infection. Objective: To assess the prevalence of Hepatitis B and C virus among blood donors at National Blood Bank, Addis Ababa, Ethiopia 2015-2017 Method and Materials: An insitution-based retrospective cross-sectional sudy was conducted on the prevalence of Hepatitis B and C among 909 blood donors at the National Blood Bank of Ethiopia in 2017 using a sysematic randomized sampling technique. The data was analyzed using SPSS version 20 software and sated descriptively. Results: The current sudy identifed that the prevalence of hepatitis B and C were 24(2.6%) and 7 (0.8%) among volunteer blood downers respectively. The prevalence of hepatitis B is identifed to be 9(2.7%) and 15(2.6%) among females and males correspondingly. Whereas, the commonness of the hepatitis is found to be 3.7% among under 40 years old volunteer blood downers. Conclusion: Hepatitis B and C virus are public health important cases Recommendation: Public health education on hepatitis infection, pre blood donation screening, and improve donors’ knowledge about the diseases. Keywords: Hepatitis B; Hepatitis C; Prevalence Introduction Statements of the problem Hepatitis B virus (HBV) infection is one of the mos serious and prevalent diseases, afecting more than 2 billion people globally [1]. Hepatitis C is also a major global health problem afecting all countries, it is esimated that approximately 80 million people worldwide [2]. In Asian and Wesern Pacifc countries where the hepatitis B virus (HBV) is endemic, the esimated prevalence of chronic HBV infection ranges from 2.4% to 16.0% [3]. The prevalence of hepatitis C virus (HCV) and HBV were 33 (8.5%) and 37 (9.5%), respectively. [4]. In Ethiopia, although nationwide survey report is lack, an esimated prevalence of HBV and HCV infection was 10%-15% and 2%-5 % respectively [5]. The prevalence of HBV seropositive among blood donors was 4.11-6.2% [5,6]. The prevalence of major bloodborne pathogens among blood donors in Ethiopia was 43.2%; of which