All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Atribution License. Socio-environmental vulnerability in the São Paulo Macro-metropolis’ three main metropolitan regions: a socio-environmental indicators analysis indicators analysis Abstract: In this article, the concept of socio-environmental vulnerabil- ity is empirically operationalized, with the objective of analyzing situ- ations of socio-environmental vulnerability on intra-urban scale, in a group of 62 municipalities in the three main metropolitan regions of the Macro-metropolis of São Paulo State. The methodology associates two concepts from the recent literature on vulnerability – one social and the other physical-environmental – through an index that integrates socio-demographic indicators from the 2010 Demographic Census with cartographies of areas susceptible to floods and landslides. The results show that 1.8 million people live in areas with high socio-environmen- tal vulnerability that have significantly worse socioeconomic conditions than areas with low and moderate vulnerability, especially regarding the differences in sewage coverage, in the surroundings of households and in the population living in substandard settlements (slums). Keywords: Socio-environmental vulnerability; socio-environmental indicators; Macro-metropolis of São Paulo State. Humberto Prates da Fonseca Alves I São Paulo. Vol. 24, 2021 Original Article DOI: http://dx.doi.org/10.1590/1809-4422asoc20200030r2vu2021L1AO I Associate Professor at the Fe- deral University of São Paulo (Unifesp), Department of Social Sciences, Guarulhos Unifesp Campus, Guarulhos, São Paulo, Brazil.